兰普伦对培养的人体细胞的作用。
The effect of Lampren on human cells in culture.
作者信息
Delhanty J D, Attwood J, Wilkie D
出版信息
Br J Exp Pathol. 1974 Feb;55(1):13-9.
The rimino phenazine, Lampren, substantially inhibits mitosis and cell growth in cultured human fibroblasts at concentrations as low as 2·5 μg/ml; lethal effects were evident at high doses. Cells exposed to 5 μg/ml of the drug for not more than 24 hours had begun to recover by the third day with the appearance of mitoses. The addition of small amounts of the drug to respiring cells markedly stimulated oxygen uptake by the cells; at high concentrations oxygen uptake was depressed, demonstrating a direct effect of the drug on respiration.
利美吩嗪（Lampren）在低至2.5μg/ml的浓度下就能显著抑制培养的人成纤维细胞的有丝分裂和细胞生长；高剂量时会产生明显的致死效应。暴露于5μg/ml该药物不超过24小时的细胞，到第三天随着有丝分裂的出现开始恢复。向正在呼吸的细胞中添加少量该药物会显著刺激细胞对氧气的摄取；在高浓度时氧气摄取受到抑制，表明该药物对呼吸有直接作用。
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