Baskerville A, Thomas G, Wood M, Harris W J
Br J Exp Pathol. 1974 Apr;55(2):130-7.
Mice and hamsters were infected with the NWS strain of influenza virus and metaplastic changes which developed in the lungs during the healing phase were studied by histology and electron microscopy. Transformation of alveolar epithelium occurred in many animals, producing alveolar epithelialization. This was due to replacement of the normal alveolar epithelium by ciliated columnar and cuboidal cells of bronchiolar type. Squamous changes also developed in healing lungs during the 11-22 day period after infection. Since these lesions regressed later and the cells did not metastasize they were considered to be metaplastic rather than neoplastic in nature.
将小鼠和仓鼠感染流感病毒NWS株，并通过组织学和电子显微镜研究愈合阶段肺部出现的化生变化。许多动物出现肺泡上皮转化，导致肺泡上皮化生。这是由于正常肺泡上皮被细支气管型的纤毛柱状和立方细胞所取代。感染后11 - 22天期间，愈合中的肺部也出现鳞状变化。由于这些病变后来消退且细胞未转移，它们在本质上被认为是化生而非肿瘤性的。
