Domino E F, Krause R R, Thiessen M M, Batsakis J G
Arch Gen Psychiatry. 1975 Jun;32(6):717-21. doi: 10.1001/archpsyc.1975.01760240045003.
Whole blood, plasma, or serum levels of various components were measured in fasting, drug-free control subjects and drug-free schizophrenic patients. Compared to normal controls, chronic schizophrenic patients showed increased alpha2-globulins and decreased plasma cholinesterase activity and ceruloplasmin activity, and acute schizophrenic patients showed decreased alpha2-globulins. Compared to chronic patients, acute schizophrenics showed decreased alpha2-globulins and IgA. Compared to normal controls of similar age, chronic schizophrenic patients weighed less, were shorter, and had smaller body surface area. The acute schizophrenic patients were significantly younger than the normal subjects or chronic schizophrenics but there was no difference in the other physical measurements. The present study indicates no gross disturbances in the blood variables studied. That some differences are statistically significant from controls is of scientific interest, but of no clinical value in the diagnosis of schizophrenia.
在空腹且未服用药物的对照受试者以及未服用药物的精神分裂症患者中，测量了全血、血浆或血清中各种成分的水平。与正常对照组相比，慢性精神分裂症患者的α2球蛋白增加，血浆胆碱酯酶活性和铜蓝蛋白活性降低，而急性精神分裂症患者的α2球蛋白降低。与慢性患者相比，急性精神分裂症患者的α2球蛋白和IgA降低。与年龄相仿的正常对照组相比，慢性精神分裂症患者体重较轻、身高较矮且体表面积较小。急性精神分裂症患者明显比正常受试者或慢性精神分裂症患者年轻，但在其他身体测量方面没有差异。本研究表明，所研究的血液变量没有明显紊乱。虽然有些差异与对照组相比在统计学上具有显著性，但在精神分裂症的诊断中没有临床价值。
