抗生素与犬血清蛋白的结合率。
Rate of binding of antibiotics to canine serum protein.
作者信息
Waterman N, Scharfenberger L, Raff M J
出版信息
Antimicrob Agents Chemother. 1974 Mar;5(3):294-5. doi: 10.1128/AAC.5.3.294.
Abstract
The time rates of binding of three antibiotics of similar chemical structure, each with differing degrees of protein binding, were determined. Cephaloridine, which is 10% bound by serum proteins, was bound at a more rapid rate than cephalothin, which is 40% bound by serum protein. Cefazolin, bound 80%, required for longest time period for maximum binding to occur. The rate of protein binding appears directly related to the total percentage bound. The data from this study indicate that prolonged rates of binding of highly protein-bound drugs may influence pharmacological studies.
摘要
测定了三种化学结构相似但蛋白结合程度不同的抗生素的结合时间速率。头孢菌素，其10%与血清蛋白结合，其结合速率比头孢噻吩更快，头孢噻吩40%与血清蛋白结合。头孢唑林，80%被结合，达到最大结合所需的时间最长。蛋白结合速率似乎与结合的总百分比直接相关。这项研究的数据表明，高蛋白结合药物的延长结合速率可能会影响药理学研究。
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