Waterman N G, Eickenberg H U, Scharfenberger L
Antimicrob Agents Chemother. 1976 Oct;10(4):733-5. doi: 10.1128/AAC.10.4.733.
Cefamandole readily diffuses from the serum into soft tissue interstitial fluid. The rate of diffusion differs little from that of cephalothin. The concentrations of antibiotic were greater in bile and urine during the entire period of study than is necessary to kill susceptible pathogenic bacteria present in these fluids.
头孢孟多易于从血清中扩散到软组织间质液中。其扩散速率与头孢噻吩的扩散速率相差不大。在整个研究期间,胆汁和尿液中的抗生素浓度高于杀死这些液体中存在的敏感病原菌所需的浓度。