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头孢孟多在血清、组织间液、胆汁及尿液中的浓度。

Concentration of cefamandole in serum interstitial fluid, bile, and urine.

作者信息

Waterman N G, Eickenberg H U, Scharfenberger L

出版信息

Antimicrob Agents Chemother. 1976 Oct;10(4):733-5. doi: 10.1128/AAC.10.4.733.

Abstract

Cefamandole readily diffuses from the serum into soft tissue interstitial fluid. The rate of diffusion differs little from that of cephalothin. The concentrations of antibiotic were greater in bile and urine during the entire period of study than is necessary to kill susceptible pathogenic bacteria present in these fluids.

摘要

头孢孟多易于从血清中扩散到软组织间质液中。其扩散速率与头孢噻吩的扩散速率相差不大。在整个研究期间,胆汁和尿液中的抗生素浓度高于杀死这些液体中存在的敏感病原菌所需的浓度。

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Cefamandole: in vitro and clinical pharmacokinetics.头孢孟多:体外及临床药代动力学
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本文引用的文献

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Pathophysiology of tissue fluid.组织液的病理生理学
Proc R Soc Med. 1972 Aug;65(8):715-9. doi: 10.1177/003591577206500822.
3
Interstitial fluid and serum antibiotic concentrations.组织液和血清抗生素浓度。
Arch Surg. 1972 Aug;105(2):192-6. doi: 10.1001/archsurg.1972.04180080046008.
4
Rapid microassay for circulating nephrotoxic antibiotics.循环肾毒性抗生素的快速微量测定法。
Antimicrob Agents Chemother (Bethesda). 1970;10:83-90. doi: 10.1128/AAC.10.1.83.
5
Rate of binding of antibiotics to canine serum protein.抗生素与犬血清蛋白的结合率。
Antimicrob Agents Chemother. 1974 Mar;5(3):294-5. doi: 10.1128/AAC.5.3.294.
8
10
Concentration of antibiotics in renal interstitial fluid: an experimental model.
Urol Res. 1975 Dec 30;3(4):165-7. doi: 10.1007/BF00261952.

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