Fink B R, Kish S J, Byers M R
Brain Res. 1975 Jun 6;90(1):85-95. doi: 10.1016/0006-8993(75)90684-8.
The rat trigeminal nerve was investigated as a model system for axonal transport to identifiable sensory nerve endings. Following stereotaxic injection of [3-H]proline into the ganglion, the distribution of label in protein and other extracts of ligated or unligated infraorbital nerve was measured in replicates at various time intervals from 30 min to 3 days. In unligated nerves the average maximum velocity of somatofugal protein transport was 228 mm/day. Light microscope autoradiography demonstrated rapid intraaxonal transport of radioactive material to nerve endings in molar teeth and vibrissae. The system appears suitable for investigating the fate of axonally transported material at peripheral receptors.
将大鼠三叉神经作为轴突运输至可识别感觉神经末梢的模型系统进行了研究。在立体定位下将[3-H]脯氨酸注入神经节之后，在30分钟至3天的不同时间间隔重复测量结扎或未结扎眶下神经的蛋白质及其他提取物中的标记物分布。在未结扎的神经中，躯体离心性蛋白质运输的平均最大速度为228毫米/天。光学显微镜放射自显影显示放射性物质在轴突内快速运输至磨牙和触须的神经末梢。该系统似乎适合用于研究外周感受器处轴突运输物质的去向。
