• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

中链甘油三酯与肝性脑病

Medium chain triglycerides and hepatic encephalopathy.

作者信息

Morgan M H, Bolton C H, Morris J S, Read A E

出版信息

Gut. 1974 Mar;15(3):180-4. doi: 10.1136/gut.15.3.180.

DOI:10.1136/gut.15.3.180
PMID:4841275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412890/
Abstract

The oral administration of short (C(6)) and medium (C(8) and (C(10)) chain triglycerides produced no clinical or electroencephalographic changes in patients with cirrhosis of the liver. Arterial ammonia levels were also monitored in these patients and showed no significant change after medium chain triglycerides. It was concluded that medium chain triglycerides, known to be of potential value in the treatment of malabsorption in patients with cirrhosis, are not clinically contraindicated, even in patients with evidence of hepatic encephalopathy.

摘要

对肝硬化患者口服短链(C6)和中链(C8和C10)甘油三酯后,未观察到临床或脑电图变化。同时对这些患者的动脉血氨水平进行了监测,结果显示服用中链甘油三酯后无显著变化。得出的结论是,已知中链甘油三酯在治疗肝硬化患者吸收不良方面具有潜在价值,即使对有肝性脑病迹象的患者,临床上也没有禁忌。

相似文献

1
Medium chain triglycerides and hepatic encephalopathy.中链甘油三酯与肝性脑病
Gut. 1974 Mar;15(3):180-4. doi: 10.1136/gut.15.3.180.
2
Plasma long chain fatty acids and esterified lipids in cirrhosis and hepatic encephalopathy.肝硬化和肝性脑病中的血浆长链脂肪酸及酯化脂质
Am J Med Sci. 1978 Nov-Dec;276(3):293-303. doi: 10.1097/00000441-197811000-00006.
3
[Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)].接受螺内酯治疗的肝硬化患者的高氨血症和肝性脑病(作者译)
Nouv Presse Med. 1977 Nov 5;6(37):3407-10.
4
Ammonia metabolism in the gut.
Am J Clin Nutr. 1970 May;23(5):633-9. doi: 10.1093/ajcn/23.5.633.
5
Transfer of medium chain fatty acids from blood to spinal fluid in patients with cirrhosis.肝硬化患者中中链脂肪酸从血液到脑脊液的转运
Gastroenterology. 1970 Apr;58(4):509-15.
6
Effect of medium-chain triglycerides on liver fatty acid composition in alcoholics with or without cirrhosis.中链甘油三酯对伴有或不伴有肝硬化的酗酒者肝脏脂肪酸组成的影响。
Am J Clin Nutr. 1973 Jul;26(7):738-43. doi: 10.1093/ajcn/26.6.738.
7
[The use of LCT- and MCT-containing fat emulsions in liver cirrhosis].[含长链甘油三酯和中链甘油三酯的脂肪乳剂在肝硬化中的应用]
Beitr Infusionther Klin Ernahr. 1988;20:165-78.
8
Oral keto analogs of branched-chain amino acids in hyperammonemia in patients with cirrhosis of the liver. A double-blind crossover study.
Digestion. 1982;24(2):105-11. doi: 10.1159/000198784.
9
Recent developments in the pathophysiology and treatment of hepatic encephalopathy.肝性脑病的病理生理学与治疗的最新进展
Baillieres Clin Gastroenterol. 1992 Sep;6(3):609-30. doi: 10.1016/0950-3528(92)90041-c.
10
Effects of oral branched-chain amino acids on hepatic encephalopathy and outcome in patients with liver cirrhosis.口服支链氨基酸对肝硬化患者肝性脑病及预后的影响。
Nutr Clin Pract. 2013 Oct;28(5):580-8. doi: 10.1177/0884533613496432. Epub 2013 Aug 14.

引用本文的文献

1
Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment.乳糜性腹水:发病机制、诊断与治疗综述
J Clin Transl Hepatol. 2018 Mar 28;6(1):105-113. doi: 10.14218/JCTH.2017.00035. Epub 2017 Dec 4.
2
The why and wherefore of hepatic encephalopathy.肝性脑病的原因及缘由
Int J Gen Med. 2015 Dec 16;8:381-90. doi: 10.2147/IJGM.S86854. eCollection 2015.
3
Plasma concentrations and central nervous system effects of the new hypnotic agent zopiclone in patients with chronic liver disease.新型催眠药佐匹克隆在慢性肝病患者中的血浆浓度及对中枢神经系统的影响。
Br J Clin Pharmacol. 1983 Sep;16(3):259-65. doi: 10.1111/j.1365-2125.1983.tb02159.x.
4
Intravenous administration of diazepam in patients with chronic liver disease.慢性肝病患者静脉注射地西泮
Gut. 1976 Dec;17(12):975-83. doi: 10.1136/gut.17.12.975.
5
Some clinical features of liver cell failure: an appraisal of their causes.肝细胞衰竭的一些临床特征:对其病因的评估。
Gut. 1978 Jun;19(6):543-8. doi: 10.1136/gut.19.6.543.

本文引用的文献

1
[EFFECT OF SHORT-CHAIN FATTY ACIDS ON THE ELECTRICAL ACTIVITY OF THE NEO-, PALEO-, AND ARCHICORTICAL SYSTEM].
No To Shinkei. 1964 Jul;16:601-8.
2
Differences in absorption of the various fatty acids studied in children with steatorrhea.脂肪泻患儿中所研究的各种脂肪酸吸收情况的差异。
J Clin Invest. 1962 Mar;41(3):488-94. doi: 10.1172/JCI104502.
3
Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
J Biol Chem. 1960 Sep;235:2595-9.
4
The measurement of ammonia in whole blood, erythrocytes, and plasma.全血、红细胞和血浆中氨的测定。
J Lab Clin Med. 1957 Jun;49(6):962-74.
5
A study on the narcotic action of the short chain fatty acids.短链脂肪酸的麻醉作用研究。
J Clin Invest. 1956 Nov;35(11):1291-8. doi: 10.1172/JCI103384.
6
Effects of fatty acid anions on the electroencephalogram of unanesthetized rabbits.
Am J Physiol. 1956 Aug;186(2):271-4. doi: 10.1152/ajplegacy.1956.186.2.271.
7
The plasma ammonia and glutamine content in patients with hepatic coma.肝昏迷患者的血浆氨和谷氨酰胺含量。
J Clin Invest. 1954 Jul;33(7):984-8. doi: 10.1172/JCI102976.
8
Medium and long chain fat absorption in patients with cirrhosis.肝硬化患者中、长链脂肪的吸收
J Clin Invest. 1966 Aug;45(8):1317-25. doi: 10.1172/JCI105438.
9
Medium-chain triglyceride diet: its use in treatment of liver disease.中链甘油三酯饮食:其在肝病治疗中的应用。
Br Med J. 1966 Oct 29;2(5521):1050-1. doi: 10.1136/bmj.2.5521.1050.
10
Effects of chlorpromazine in patients with hepatic disease.氯丙嗪对肝病患者的影响。
Br Med J. 1969 Aug 30;3(5669):497-9. doi: 10.1136/bmj.3.5669.497.