氯丙嗪对肝病患者的影响。
Effects of chlorpromazine in patients with hepatic disease.
作者信息
Read A E, Laidlaw J, McCarthy C F
出版信息
Br Med J. 1969 Aug 30;3(5669):497-9. doi: 10.1136/bmj.3.5669.497.
Abstract
Patients with cirrhosis were found to be extremely sensitive to chlorpromazine as shown by slowing of the electroencephalograph (E.E.G.), which was particularly definite in those who had had hepatic encephalopathy previously. Patients showing the most definite E.E.G. changes were in general very sleepy and took some hours to recover after taking chlorpromazine. It is concluded that phenothiazine drugs should be used very cautiously in patients with alcoholic liver disease.
摘要
肝硬化患者被发现对氯丙嗪极为敏感，脑电图（E.E.G.）减慢表明了这一点，这在既往有肝性脑病的患者中尤为明显。脑电图变化最明显的患者通常非常嗜睡，服用氯丙嗪后需要数小时才能恢复。结论是，在酒精性肝病患者中应非常谨慎地使用吩噻嗪类药物。
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