Brandt M R, Olgaard K, Kehlet H
Acta Anaesthesiol Scand. 1979 Jun;23(3):267-72. doi: 10.1111/j.1399-6576.1979.tb01450.x.
Renin activity and aldosterone concentration in plasma and excretion of sodium and potassium in urine were measured during a period of 24 hours in 12 patients undergoing hysterectomy under general anaesthesia or epidural analgesia. Analgesia extended from T4 to S5 and was effective throughout the study. The normal stress-induced increase in plasma renin activity and aldosterone was inhibited by epidural analgesia. Urinary excretion of potassium was significantly lower in the epidural group, but sodium and water retention showed no difference between groups. It is concluded that neurogenic stimuli from the surgical area are important release mechanisms of the renin-aldosterone response to surgery. The results suggest that post-operative sodium retention is caused by factors other than the mineralocorticoid system.
在全身麻醉或硬膜外镇痛下行子宫切除术的12例患者中，于24小时内测定了血浆肾素活性、醛固酮浓度以及尿钠和尿钾排泄量。镇痛范围从T4至S5，且在整个研究过程中均有效。硬膜外镇痛抑制了正常应激诱导的血浆肾素活性和醛固酮的升高。硬膜外组的尿钾排泄显著降低，但两组间钠和水潴留无差异。结论是手术区域的神经源性刺激是肾素 - 醛固酮对手术反应的重要释放机制。结果提示术后钠潴留是由盐皮质激素系统以外的因素引起的。
