Turkel S B, Itabashi H H
Am J Pathol. 1974 Aug;76(2):225-44.
A study was made of neuroblastic nodules of the human adrenal gland in fetal life to determine their embryonic morphology and derivation. One hundred sixty-nine glands from 92 fetuses selected from 106 consecutively submitted fetuses formed the basis of this study. All adrenal glands examined contained neuroblastic nodules. They increased in number and maximum size with increasing age, peaked at 17 to 20 weeks gestational age, and regressed in the oldest fetuses. It is concluded that such neuroblastic nodules are an integral part of the normal morphogenesis of the adrenal gland. Their presence at birth and early infancy may represent a normal variation, and they do not necessarily constitute microscopic incipient malignancy.
对胎儿期人类肾上腺的神经母细胞结节进行了一项研究，以确定其胚胎形态和起源。从连续提交的106例胎儿中选取92例胎儿的169个肾上腺作为本研究的基础。所有检查的肾上腺均含有神经母细胞结节。它们的数量和最大尺寸随年龄增加而增加，在孕龄17至20周时达到峰值，在最年长的胎儿中则逐渐消退。结论是，这种神经母细胞结节是肾上腺正常形态发生的一个组成部分。它们在出生时和婴儿早期的存在可能代表一种正常变异，并不一定构成微观上的早期恶性肿瘤。
