Iliff L, Zilkha E, Bull J W, Du Boulay G H, McAllister V L, Marshall J, Russell R W, Symon L
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):631-5. doi: 10.1136/jnnp.37.6.631.
Regional cerebral blood flow was measured by injection of (133)Xenon into the internal carotid artery in 11 patients with cerebrovascular disease. All patients were studied under general anaesthesia, first at normocapnia and then at hypocapnia. The 15 minute isotope clearance curves were analysed by computer by two-compartmental analysis and regional changes in flow and the proportions of fast and slow clearing tissue obtained at two levels of arterial CO(2) tension. Hypocapnia caused a fall in blood flow which was consistently accompanied by a decrease in the proportion of fast clearing tissue. Regional changes were not significantly different from the hemisphere mean changes. There was no correlation between changes in blood flow through grey matter and the proportion of fast clearing tissue on a hemisphere mean basis, but on regional analysis the data from 10 out of the 11 patients showed that in areas where blood flow through grey matter changed most the proportion of fast clearing tissue changed least and vice versa. A hypothesis has been proposed to explain this phenomenon.
通过向11例脑血管疾病患者的颈内动脉注射氙-133来测量局部脑血流量。所有患者均在全身麻醉下进行研究，首先在正常碳酸血症时，然后在低碳酸血症时。通过计算机采用两室分析法分析15分钟的同位素清除曲线，并在两个动脉二氧化碳分压水平下获得血流的区域变化以及快速和缓慢清除组织的比例。低碳酸血症导致血流下降，同时快速清除组织的比例持续降低。区域变化与半球平均变化无显著差异。在半球平均基础上，灰质血流量的变化与快速清除组织的比例之间无相关性，但在区域分析中，11例患者中有10例的数据表明，在灰质血流量变化最大的区域，快速清除组织的比例变化最小，反之亦然。已提出一个假说来解释这一现象。
