Eintrei C, Malmqvist L A, Lund N, Lewis D H
Int J Microcirc Clin Exp. 1985;4(4):373-8.
A method for measuring regional cerebral blood flow with local application of 133Xenon was used. A polyester film was placed on pig cerebral cortex under which 0.6-1.3 mCi of 133Xenon dissolved in 2-4 microliter of saline was applied atraumatically. The wash-out process was registered with an external detector. The wash-out curves were not contaminated by extra-cerebral tissue and there was no 'looking-through phenomenon' of non-perfused parts of the brain. Regional cerebral blood flow was 142 +/- 14 ml X 100 g-1 X min-1 (mean +/- S.D.) in grey matter and 34 +/- 9 ml X 100 g-1 X min-1 in white matter when PaCO2 was normal (4.92 +/- 0.43 kPa). When PaCO2 was increased to 9.3 +/- 1.39 kPa regional cerebral blood flow was increased to 313 +/- 60 ml X 100 g-1 X min-1 in grey matter and to 46 +/- 20 ml X 100g-1 X min-1 in white matter.
采用局部应用133氙测量局部脑血流量的方法。将聚酯薄膜置于猪脑皮层上，在其下方无创地施加溶解于2 - 4微升生理盐水中的0.6 - 1.3毫居里133氙。用外部探测器记录洗脱过程。洗脱曲线未受脑外组织污染，且不存在脑非灌注部分的“穿透现象”。当动脉血二氧化碳分压（PaCO2）正常（4.92±0.43千帕）时，灰质局部脑血流量为142±14毫升×100克-1×分钟-1（平均值±标准差），白质为34±9毫升×100克-1×分钟-1。当PaCO2升高至9.3±1.39千帕时，灰质局部脑血流量增加至313±60毫升×100克-1×分钟-1，白质增加至46±20毫升×100克-1×分钟-1。
