多发性硬化症患者脑脊液中的胺类代谢产物。
Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis.
作者信息
Claveria L E, Curzon G, Harrison M J, Kantamaneni B D
出版信息
J Neurol Neurosurg Psychiatry. 1974 Jun;37(6):715-8. doi: 10.1136/jnnp.37.6.715.
Abstract
Mean homovanillic acid and 5-hydroxyindoleacetic acid concentrations were significantly low in the lumbar CSF of a group of patients with disseminated sclerosis (DS) who were severely disabled but not in the CSF of a less severely restricted group with DS. CSF concentrations were also low in a group of patients with superior cerebellar peduncular tremor due to DS and in a single patient with a similar tremor associated with a post-traumatic brain-stem lesion. The interpretation of abnormal CSF amine metabolite concentrations is discussed in the light of these findings.
摘要
在一组严重残疾的多发性硬化症（DS）患者的腰椎脑脊液中，高香草酸和5-羟吲哚乙酸的平均浓度显著降低，但在病情限制较轻的DS患者脑脊液中则未降低。因DS导致小脑上脚震颤的一组患者以及一名患有与创伤后脑干病变相关的类似震颤的患者，其脑脊液浓度也较低。根据这些发现对脑脊液胺代谢物浓度异常的解释进行了讨论。
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