坎塔马内尼·B·D，柯尔森·G：帕金森病中左旋多巴的益处与脑脊液中胺代谢产物增加的比较。
Kantamaneni BD, Curzon G:Comparison of benefit from L-dopa in Parkinsonism with increase of amine metabolites in the CSF.
作者信息
Godwin-Austen R B
出版信息
J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):219-23. doi: 10.1136/jnnp.34.3.219.
Abstract
Homovanillic acid (HVA) and 5-hydroxy indole acetic acid (5-HIAA) concentrations have been estimated in the cerebrospinal fluid (CSF) of 16 and 18 patients respectively with Parkinsonism both before and during treatment with l-dopa. The rise of HVA correlated with dose of l-dopa. An increase of HVA concentration to less than 0·10 μg/ml. was associated with little or no clinical improvement. The five patients with the greatest increase of HVA concentration/g l-dopa showed little or no improvement from treatment and four of these patients had normal pre-treatment HVA and 5-HIAA. In those patients who responded well to l-dopa the CSF HVA/g l-dopa was intermediate between that of these two groups. It is suggested that change in HVA content of CSF during l-dopa treatment might be of value in the prediction of response to l-dopa.
摘要
分别测定了16例和18例帕金森病患者在左旋多巴治疗前及治疗期间脑脊液（CSF）中高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度。HVA的升高与左旋多巴的剂量相关。HVA浓度升高至低于0.10μg/ml时，临床改善很少或没有改善。HVA浓度/每克左旋多巴升高幅度最大的5例患者治疗后改善很少或没有改善，其中4例患者治疗前HVA和5-HIAA正常。在对左旋多巴反应良好的患者中，脑脊液HVA/每克左旋多巴处于这两组之间。提示左旋多巴治疗期间脑脊液中HVA含量的变化可能对预测左旋多巴的反应有价值。
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本文引用的文献
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Dopamine formation in brain capillaries--an enzymic blood-brain barrier mechanism.脑毛细血管中的多巴胺生成——一种酶促血脑屏障机制。
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Treatment of parkinsonism with levodopa.左旋多巴治疗帕金森症。
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L-dopa and cerebrospinal fluid homovanillic acid in Parkinsonism.帕金森病中的左旋多巴与脑脊液高香草酸
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