Yoshioka T, Kawada K, Shimada T, Mori M
Am J Obstet Gynecol. 1979 Oct 1;135(3):372-6. doi: 10.1016/0002-9378(79)90708-7.
Concentrations of a peroxidation product (malondialdehyde), fluorescent chromophores, lipofuscin-like fluorescent products, superoxide dismutase, catalase, glutathione peroxidase, and vitamin E in the maternal blood and the cord blood were determined and the results obtained were related to the estimation of lipid peroxidation and protective mechanism against uncontrolled oxidative processes in late pregnancy. Serum levels of fluorescent products were higher in the maternal blood than in the cord blood, indicating less frequent lipid peroxidation in the fetus than in the mother. In support of this assumption, the three protective enzymes and vitamin E were present in relatively lower concentrations in the cord blood. Sudden exposure of the newborn infant to a normobaric atmosphere after beginning breathing seems, therefore, to cause oxidation of red blood cell membrane, denaturation of the membrane, inducing hemoglobin breakdown, and consequently hemolysis.
测定了母血和脐血中过氧化产物（丙二醛）、荧光发色团、脂褐素样荧光产物、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和维生素E的浓度，并将所得结果与妊娠晚期脂质过氧化的估计以及针对不受控制的氧化过程的保护机制相关联。母血中荧光产物的血清水平高于脐血，这表明胎儿中脂质过氧化的频率低于母亲。为支持这一假设，脐血中三种保护酶和维生素E的浓度相对较低。因此，新生儿开始呼吸后突然暴露于常压环境似乎会导致红细胞膜氧化、膜变性，诱导血红蛋白分解，进而导致溶血。
