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荧光标记物在区分母源和胎儿染色体中的价值。

The value of fluorescence markers in the distinction between maternal and fetal chromosomes.

作者信息

Hauge M, Poulsen H, Halberg A, Mikkelsen M

出版信息

Humangenetik. 1975;26(3):187-91. doi: 10.1007/BF00281452.

DOI:10.1007/BF00281452
PMID:48495
Abstract

Selected fluorescence markers of chromosomes were studied in 50 paired samples of cells obtained by culture of amniocentesis material and by culture of leukocytes from pregnant women. Comparative analyses showed that this method is of great value in disclosing admixture of maternal cells to material obtained by amniocentesis, as a minimum of 2 fluorescence marker differences between mother and fetus was found in the present material. The distribution of markers in mother/fetus pairs is in agreement with the assumption of genetic determination. Variation was observed between populations with respect to the frequency of the markers studied.

摘要

对50对通过羊水穿刺材料培养和孕妇白细胞培养获得的细胞样本中的染色体选定荧光标记进行了研究。比较分析表明，该方法在揭示羊水穿刺获得的材料中母细胞的混合情况方面具有重要价值，因为在本材料中发现母亲和胎儿之间至少有2个荧光标记差异。标记在母/胎对中的分布与遗传决定的假设一致。观察到不同人群在所研究标记的频率方面存在差异。

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引用本文的文献

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2
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Human chromosome variation: the discriminatory power of Q-band heteromorphism (variant) analysis in distinguishing between individuals, with specific application to cases of questionable paternity.

本文引用的文献

1
Differential binding of alkylating fluorochromes in human chromosomes.烷化荧光染料在人类染色体中的差异结合
Exp Cell Res. 1970 Jun;60(3):315-9. doi: 10.1016/0014-4827(70)90523-9.
2
Chromosome analysis of fetuses in risk pregnancies.
Acta Obstet Gynecol Scand Suppl. 1974;29:9-14. doi: 10.3109/00016347409157184.
人类染色体变异：Q带异态性（变异）分析在个体识别中的鉴别力，特别应用于亲权存疑的案例。
Am J Hum Genet. 1986 Feb;38(2):235-52.
4
Frequency of chromosomal fluorescence polymorphism in normal persons and in clinical patients with diagnosed chromosome aberrations.正常人和已确诊染色体畸变的临床患者中染色体荧光多态性的频率。
Hum Genet. 1976 May 19;32(2):115-9. doi: 10.1007/BF00291493.
5
An abortus with a normal/trisomy 16 mosaicism: instability of trisomic cells in vitro.一例具有正常/16三体嵌合体的流产胎儿：三体细胞在体外的不稳定性
Humangenetik. 1975 Nov 6;30(2):167-71. doi: 10.1007/BF00291949.
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"Jumping" satellites in three generations: a warning for paternity tests and prenatal diagnosis.
Hum Genet. 1976 Dec 15;34(3):315-8. doi: 10.1007/BF00295297.
7
Pitfalls in the use of chromosome variants for paternity dispute cases.亲子鉴定案件中染色体变异应用的陷阱。
Hum Genet. 1977 Jul 26;37(3):255-60. doi: 10.1007/BF00393606.
8
A photometric method for quantifying the polymorphisms in human acrocentric chromosomes.一种用于定量分析人类近端着丝粒染色体多态性的光度测定法。
Hum Genet. 1977 Feb 11;35(2):185-91. doi: 10.1007/BF00393968.
9
Prenatal diagnosis: techniques used to help in ruling out maternal cell contamination.产前诊断：用于帮助排除母体细胞污染的技术。
J Med Genet. 1977 Feb;14(1):37-9. doi: 10.1136/jmg.14.1.37.
10
Chromosome polymorphism and twin zygosity.染色体多态性与双胎合子类型
Am J Hum Genet. 1977 Sep;29(5):431-47.