Zak A F, Ermolova O B
Antibiotiki. 1976 Feb;21(2):151-5.
Difference in the levels of bioavailability of 4 types of tetracycline hydrochloride tablets was shown on rabbits and guinea pigs. The rates of the antibiotic absorption into the blood of the laboratory animals and volunteers were the same. Relation between the rate of disintegration of various types of tablets of tetracycline hydrochloride and the antibiotic blood levels in the rabbits after administration of the same tablets was found.
四种盐酸四环素片的生物利用度水平在兔子和豚鼠身上表现出差异。该抗生素在实验动物和志愿者血液中的吸收速率相同。发现了不同类型盐酸四环素片的崩解速率与给兔子服用相同片剂后抗生素血药浓度之间的关系。
