大鼠体内细菌对ω-鼠胆酸的合成
Bacterial formation of omega-muricholic acid in rats.
作者信息
Sacquet E C, Raibaud P M, Mejean C, Riottot M J, Leprince C, Leglise P C
出版信息
Appl Environ Microbiol. 1979 Jun;37(6):1127-31. doi: 10.1128/aem.37.6.1127-1131.1979.
Abstract
In the feces of conventional rats, the amount of omega-muricholic and hyodeoxycholic acids vary according to the diet. To understand this phenomenon, we investigated the bacterial formation of these bile acids. The present paper reports the first isolation, from conventional rat feces, of a strain of Clostridium group III which transforms beta-muricholic acid, the main bile acid in germfree rats, into omega-muricholic acid.
摘要
在常规大鼠的粪便中，ω-鼠胆酸和猪去氧胆酸的含量会因饮食而异。为了解这一现象，我们研究了这些胆汁酸的细菌合成过程。本文首次报道了从常规大鼠粪便中分离出一株第三组梭菌，该菌株可将无菌大鼠体内的主要胆汁酸β-鼠胆酸转化为ω-鼠胆酸。
相似文献
1
Bacterial formation of omega-muricholic acid in rats.大鼠体内细菌对ω-鼠胆酸的合成
Appl Environ Microbiol. 1979 Jun;37(6):1127-31. doi: 10.1128/aem.37.6.1127-1131.1979.
2
Delta 22-beta-muricholic acid in monoassociated rats and conventional rats.单联大鼠和普通大鼠体内的δ22-β-鼠胆酸
Lipids. 1994 Apr;29(4):289-96. doi: 10.1007/BF02536334.
3
Cooperative formation of omega-muricholic acid by intestinal microorganisms.肠道微生物协同形成ω-鼠胆酸。
Appl Environ Microbiol. 1983 Jan;45(1):141-7. doi: 10.1128/aem.45.1.141-147.1983.
4
[Formation of omega-muricholic acid and fecal excretion of biliary acids in rats].[大鼠中ω-鼠胆酸的形成及胆汁酸的粪便排泄]
C R Acad Hebd Seances Acad Sci D. 1977 Feb 14;284(7):557-9.
5
Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora.从大鼠肠道微生物群中分离出的一种未鉴定的革兰氏阳性杆菌HDCA-1，可将鼠胆酸和猪胆酸转化为猪去氧胆酸。
Appl Environ Microbiol. 1999 Jul;65(7):3158-63. doi: 10.1128/AEM.65.7.3158-3163.1999.
6
Absence of transformation of beta-muricholic acid by human microflora implanted in the digestive tracts of germfree male rats.无菌雄性大鼠消化道中植入的人类微生物群对β-鼠胆酸无转化作用。
Appl Environ Microbiol. 1984 May;47(5):1167-8. doi: 10.1128/aem.47.5.1167-1168.1984.
7
Effects of cholesterol feeding on synthesis and metabolism of cholesterol and bile acids in germfree rats.胆固醇喂养对无菌大鼠胆固醇和胆汁酸合成及代谢的影响。
J Lipid Res. 1977 Nov;18(6):717-21.
8
Deconjugation of bile acids by human intestinal bacteria implanted in germ-free rats.无菌大鼠体内植入的人类肠道细菌对胆汁酸的去结合作用。
Lipids. 1987 Sep;22(9):669-71. doi: 10.1007/BF02533948.
9
Analysis of bile acids in conventional and germfree rats.常规大鼠和无菌大鼠胆汁酸的分析
J Lipid Res. 1976 Mar;17(2):107-11.
10
Formation of hyodeoxycholate from beta-muricholate in gnotobiotic rats associated with Clostridium HDCA-1.在与HDCA-1梭菌相关的悉生大鼠中，β-鼠胆酸转化为猪去氧胆酸。
Prog Clin Biol Res. 1985;181:103-6.
引用本文的文献
1
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice.6α-羟化胆酸通过 TGR5 信号转导改善膳食纤维补充小鼠的糖代谢。
Gut. 2023 Feb;72(2):314-324. doi: 10.1136/gutjnl-2021-326541. Epub 2022 Jun 13.
2
Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA).新生儿败血症导致罕见的血清胆汁酸牛磺-ω-熊去氧胆酸（TOMCA）早期升高。
Pediatr Res. 2018 Jul;84(1):66-70. doi: 10.1038/s41390-018-0007-y. Epub 2018 May 23.
3
Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen.Roux-en-Y 胃旁路手术和袖状胃切除术会引起肠道微生物群的特定变化，而不会改变肠道腔内胆汁酸的代谢。
Int J Obes (Lond). 2019 Feb;43(2):428-431. doi: 10.1038/s41366-018-0015-3. Epub 2018 Jan 30.
4
Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents.人及啮齿动物大肠中游离胆汁酸杀菌活性的综合评估。
J Lipid Res. 2017 Jun;58(6):1143-1152. doi: 10.1194/jlr.M075143. Epub 2017 Apr 12.
5
Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota.在定殖有人类微生物群的无菌小鼠中诱导法尼醇X受体信号传导。
J Lipid Res. 2017 Feb;58(2):412-419. doi: 10.1194/jlr.M072819. Epub 2016 Dec 12.
6
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.小鼠模型中微生物群与哺乳动物代谢相互作用的自上而下的系统生物学观点。
Mol Syst Biol. 2007;3:112. doi: 10.1038/msb4100153. Epub 2007 May 22.
7
Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon.胆盐对离体血管灌注大鼠结肠黏液分泌的影响。
Dig Dis Sci. 2001 Jun;46(6):1223-31. doi: 10.1023/a:1010607127822.
8
Formation of hyodeoxycholic acid from muricholic acid and hyocholic acid by an unidentified gram-positive rod termed HDCA-1 isolated from rat intestinal microflora.从大鼠肠道微生物群中分离出的一种未鉴定的革兰氏阳性杆菌HDCA-1，可将鼠胆酸和猪胆酸转化为猪去氧胆酸。
Appl Environ Microbiol. 1999 Jul;65(7):3158-63. doi: 10.1128/AEM.65.7.3158-3163.1999.
9
Delta 22-beta-muricholic acid in monoassociated rats and conventional rats.单联大鼠和普通大鼠体内的δ22-β-鼠胆酸
Lipids. 1994 Apr;29(4):289-96. doi: 10.1007/BF02536334.
10
Cooperative formation of omega-muricholic acid by intestinal microorganisms.肠道微生物协同形成ω-鼠胆酸。
Appl Environ Microbiol. 1983 Jan;45(1):141-7. doi: 10.1128/aem.45.1.141-147.1983.
本文引用的文献
1
On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154.大鼠体内猪去氧胆酸的形成。胆汁酸与类固醇154。
J Biol Chem. 1966 Feb 10;241(3):534-9.
2
Fecal neutral steroids and bile acids from germfree rats.无菌大鼠的粪便中性类固醇和胆汁酸。
J Lipid Res. 1969 Sep;10(5):495-503.
3
Direct quantitative gas chromatographic separation of C2-C6 fatty acids, methanol, and ethyl alcohol in aqueous microbial fermentation media.直接定量气相色谱法分离水性微生物发酵培养基中的C2 - C6脂肪酸、甲醇和乙醇。
Appl Microbiol. 1968 Feb;16(2):285-90. doi: 10.1128/am.16.2.285-290.1968.
4
Bile acid transformations by microbial strains belonging to genera found in intestinal contents.肠道内容物中发现的细菌属微生物菌株对胆汁酸的转化作用。
Acta Pathol Microbiol Scand. 1967;71(4):629-38. doi: 10.1111/j.1699-0463.1967.tb05183.x.
5
Isolated fecal microorganisms capable of 7-alpha-dehydroxylating bile acids.能够对胆汁酸进行7-α-脱羟基化的分离粪便微生物。
J Exp Med. 1966 Feb 1;123(2):413-32. doi: 10.1084/jem.123.2.413.
6
[Microflora of the digestive system of the rat. I. Technics of study and proposed culture media].[大鼠消化系统的微生物区系。I. 研究技术及推荐的培养基]
Ann Inst Pasteur (Paris). 1966 Apr;110(4):568-90.
7
[Comparative study of the microbial flora of the stomach, small intestine and cecum in "holoxenic" (conventional) rats and its changes after various surgical interventions: blind jejunal loops or bile duct fistulae].“全菌饲养”（常规）大鼠胃、小肠和盲肠微生物区系的比较研究及其在各种外科手术后的变化：空肠盲袢或胆管瘘
Ann Inst Pasteur (Paris). 1971 Apr;120(4):501-24.
8
[Bacterial etiology of steatorrhea observed in rats bearing an intestinal blind pouch. Deconjugation of taurocholic acid].[肠道盲袋大鼠脂肪泻的细菌病因。牛磺胆酸的去结合作用]
C R Acad Hebd Seances Acad Sci D. 1968 Dec 16;267(25):2238-40.
9
Determination of bile acid conversion potencies of intestinal bacteria by screening in vitro and subsequent establishment in germfree rats.通过体外筛选及随后在无菌大鼠中定植来测定肠道细菌的胆汁酸转化能力。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(5):691-8. doi: 10.1111/j.1699-0463.1971.tb00098.x.
10
Isolation of anaerobic bacteria from human gingiva and mouse cecum by means of a simplified glove box procedure.通过简化的手套箱程序从人牙龈和小鼠盲肠中分离厌氧细菌。
Appl Microbiol. 1969 Apr;17(4):568-76. doi: 10.1128/am.17.4.568-576.1969.
Zotero 插件