锌和镉对豚鼠补体的影响。
Effect of zinc and cadmium on guinea-pig complement.
作者信息
Amiraian K, McKinney J A, Duchna L
出版信息
Immunology. 1974 Jun;26(6):1135-44.
Zinc, cadmium or nickel ion in the presence of optimum Ca and Mg will enhance the activity of guinea-pig complement in immune haemolysis. The range of optimum concentration of Zn is 10–10 M and is influenced by the concentrations of sensitized erythrocytes (5–500 × 10) and guinea-pig complement. Enhancement by Zn is unrelated to potentiation of guinea-pig complement activity by the zinc metalloenzyme, CPAγ. These cations may participate in a late-acting step of one of the pathways proposed for the interaction of guinea-pig complement with immune aggregates; or they may, at 37°, destroy an inhibitor of immune haemolysis.
在存在最佳钙和镁的情况下，锌、镉或镍离子会增强豚鼠补体在免疫溶血中的活性。锌的最佳浓度范围是10⁻¹⁰ M，并且受致敏红细胞（5 - 500×10⁶）浓度和豚鼠补体浓度的影响。锌的增强作用与锌金属酶CPAγ对豚鼠补体活性的增强无关。这些阳离子可能参与了所提出的豚鼠补体与免疫聚集体相互作用的某一途径的后期作用步骤；或者它们在37℃时可能破坏免疫溶血的一种抑制剂。
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