Petrozzi J W, Barton J O
Arch Dermatol. 1979 Sep;115(9):1061-3.
Fluorescent sunlamp bulbs have been an effective light source for treatment of psoriasis when they are used in combination with crude coal tar. In addition to their ultraviolet B (UVB) emission, the spectral output of these bulbs contains a substantial amount of ultraviolet A (UVA). Prior testing with this light source and topically applied methoxsalen achieved excellent results in psoriasis. This study compared topically applied methoxsalen to crude coal tar in 16 patients who had plaque-type psoriasis, using the same fluorescent sunlamp source of irradiation. Fourteen of 16 patients had complete clearing of plaques when they were treated with methoxsalen, compared with six patients who had complete clearing with the tar treatment. These results indicate that the use of methoxsalen and ultraviolet light may be more effective than tar, when used as they were in this study. The advantages of a clean, white, nonstaining topical agent also makes outpatient therapy more cosmetically acceptable.
荧光太阳灯灯泡与粗煤焦油联合使用时，一直是治疗银屑病的有效光源。除了发射紫外线B（UVB）外，这些灯泡的光谱输出还包含大量的紫外线A（UVA）。此前使用这种光源和局部应用甲氧沙林对银屑病进行的测试取得了优异的效果。本研究在16例斑块型银屑病患者中，使用相同的荧光太阳灯照射源，比较了局部应用甲氧沙林和粗煤焦油的效果。16例患者中有14例在接受甲氧沙林治疗时斑块完全消退，而接受焦油治疗的患者中有6例完全消退。这些结果表明，按照本研究中的使用方式，甲氧沙林与紫外线联合使用可能比焦油更有效。一种清洁、白色、不染色的局部用药的优点还使门诊治疗在美容方面更易被接受。
