Hanke C W, Steck W D, Roenigk H H
Arch Dermatol. 1979 Sep;115(9):1074-7. doi: 10.1001/archderm.115.9.1074.
In the treatment of psoriatic patients with psoralens plus long-wave ultraviolet radiation (PUVA), clearing of psoriatic lesions was obtained more quickly and with smaller doses of ultraviolet light when topically applied corticosteroid therapy was added. Twelve patients with symmetrical plaque-type psoriasis were given PUVA on one side of the body and PUVA plus betamethasone valerate on the other side in a paired comparison study. Ten of the patients had faster clearing of lesions on the side that was treated with PUVA and betamethasone than on the side treated with PUVA alone. The other two patients had equal clearing on both sides. All patients remained clear of lesions during maintenance with PUVA alone for at least five months after steroid therapy was discontinued. Combination therapy may save the patient time, expense, and unnecessary exposure to radiant energy.
在用补骨脂素加长波紫外线辐射（PUVA）治疗银屑病患者时，添加局部应用皮质类固醇疗法可更快清除银屑病皮损，且所需紫外线剂量更小。在一项配对比较研究中，12例对称性斑块型银屑病患者身体一侧接受PUVA治疗，另一侧接受PUVA加戊酸倍他米松治疗。其中10例患者接受PUVA加倍他米松治疗的一侧皮损清除速度比仅接受PUVA治疗的一侧更快。另外2例患者两侧皮损清除情况相同。在停用类固醇治疗后，所有患者仅用PUVA维持治疗期间至少五个月未出现皮损复发。联合治疗可节省患者的时间、费用以及不必要的辐射能暴露。
