Arch Dermatol. 1979 May;115(5):576-9. doi: 10.1001/archderm.115.5.576.
A clinical cooperative study involving 14 centers evaluated photochemotherapy (psoralen and high-intensity long-wave ultraviolet light [PUVA]) for psoriasis. Results from 465 patients treated with a PUVA-48 unit (equipped with 48 high-intensity UVA bulbs) and 110 patients treated with a PUVA-64 unit (equipped with 64 high-intensity UVA bulbs) confirmed the effectiveness of photochemotherapy for psoriasis. Clearing of psoriasis occurred in 85% of patients on PUVA-48 therapy. Mean number of treatments, joules per square centimeter, to clear, and total joules at clearing were similar to other reported trials. The plateau method of clearing resulted in lower joules per square centimeter at clearing, total joules per square centimeter, and number of treatments than the nonplateau method. Maintenance therapy groups were mainly M1 (once weekly) or M4 (no treatment for more than 60 days). No meaningful laboratory abnormalities were detected and ophthalmologic examinations showed a few abnormal results following PUVA. Short-term side effects were mainly erythema, nausea, and pruritus. The effectiveness and short-term safety of PUVA for psoriasis has now been confirmed by a second large cooperative study.
一项涉及14个中心的临床合作研究评估了光化学疗法（补骨脂素与高强度长波紫外线[PUVA]）治疗银屑病的效果。465例接受PUVA - 48治疗单元（配备48个高强度UVA灯泡）治疗的患者以及110例接受PUVA - 64治疗单元（配备64个高强度UVA灯泡）治疗的患者的结果证实了光化学疗法对银屑病的有效性。接受PUVA - 48治疗的患者中85%的银屑病得到清除。清除所需的平均治疗次数、每平方厘米焦耳数以及清除时的总焦耳数与其他报道的试验相似。与非平稳方法相比，平稳清除方法在清除时每平方厘米所需焦耳数、每平方厘米总焦耳数以及治疗次数更低。维持治疗组主要为M1（每周一次）或M4（超过60天不治疗）。未检测到有意义的实验室异常，眼科检查显示PUVA治疗后有一些异常结果。短期副作用主要为红斑、恶心和瘙痒。第二项大型合作研究现已证实了PUVA治疗银屑病的有效性和短期安全性。
