利福平在正常及慢性肉芽肿病多形核白细胞中的细胞内杀菌作用。
Intracellular bactericidal effects of rifampicin in both normal and chronic ganulomatous disease polymorphs.
作者信息
Ezer G, Soothill J F
出版信息
Arch Dis Child. 1974 Jun;49(6):463-6. doi: 10.1136/adc.49.6.463.
Abstract
Chronic granulomatous disease (CGD) polymorphs incubated with rifampicin before or after staphylococcal phagocytosis inactivated the bacteria. Lysates of normal polymorphs incubated with rifampicin inactivated bacteria. These effects were not due to damage to the polymorphs. Polymorph lysates of rifampicin-treated CGD patients and healthy subjects inactivated bacteria, but the polymorphs of rifampicin-treated CGD patients did not kill the bacteria The role of rifampicin in the treatment of CGD patients and of other patients with intracellular infections is discussed.
摘要
慢性肉芽肿病（CGD）的多形核白细胞在吞噬葡萄球菌之前或之后与利福平一起孵育可使细菌失活。正常多形核白细胞的裂解物与利福平一起孵育可使细菌失活。这些作用并非由于对多形核白细胞的损伤所致。经利福平治疗的CGD患者和健康受试者的多形核白细胞裂解物可使细菌失活，但经利福平治疗的CGD患者的多形核白细胞不能杀死细菌。文中讨论了利福平在治疗CGD患者及其他细胞内感染患者中的作用。
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In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.人多形核白细胞的体外杀菌能力：儿童慢性肉芽肿病中活性降低。
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