关于肿瘤中存在的转运核糖核酸（tRNA）的甲基化嘌呤含量
On the methylated purine content of tRNA present in tumours.
作者信息
Ho Y, Lin H
出版信息
Br J Cancer. 1974 Apr;29(4):324-7. doi: 10.1038/bjc.1974.74.
Abstract
The methylated purine content of tRNA bulk extracted from human hepatomata has been compared with that in normal human liver. The analyses were carried out with the aid of ion-exchange chromatography. The molar proportions of 5 bases detected in acid hydrolysates of tumour tRNA (N(2)-methylguanine, 1-methylguanine, 7-methylguanine, N(2)-dimethylguanine and 1-methyladenine) were not abnormally elevated.
摘要
从人肝癌组织中大量提取的tRNA的甲基化嘌呤含量已与人正常肝脏中的进行了比较。分析借助离子交换色谱法进行。在肿瘤tRNA的酸水解产物中检测到的5种碱基（N(2)-甲基鸟嘌呤、1-甲基鸟嘌呤、7-甲基鸟嘌呤、N(2)-二甲基鸟嘌呤和1-甲基腺嘌呤）的摩尔比例没有异常升高。
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