• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The reactivatibility of cholinesterase inhibited by VX and sarin in man.

作者信息

Sidell F R, Groff W A

出版信息

Toxicol Appl Pharmacol. 1974 Feb;27(2):241-52. doi: 10.1016/0041-008x(74)90195-1.

DOI:10.1016/0041-008x(74)90195-1
PMID:4855029
Abstract
摘要

相似文献

1
The reactivatibility of cholinesterase inhibited by VX and sarin in man.
Toxicol Appl Pharmacol. 1974 Feb;27(2):241-52. doi: 10.1016/0041-008x(74)90195-1.
2
Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.用于重新激活被沙林和VX模拟物抑制的胆碱酯酶的新型脑穿透性肟类化合物。
Ann N Y Acad Sci. 2016 Jun;1374(1):52-8. doi: 10.1111/nyas.13053. Epub 2016 May 6.
3
In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker.带有二甲苯连接基的双吡啶肟对沙林抑制的电鳗乙酰胆碱酯酶的体外再生作用
Eur J Med Chem. 2009 Mar;44(3):1326-30. doi: 10.1016/j.ejmech.2008.02.020. Epub 2008 Mar 5.
4
Effects of 1,1'-oxydimethylene bis-(4-tert-butylpyridinium chloride) (SAD-128) and decamethonium on reactivation of soman- and sarin-inhibited cholinesterase by oximes.
Biochem Pharmacol. 1978 Mar 1;27(5):757-61. doi: 10.1016/0006-2952(78)90516-6.
5
[The effect of the oxime HI-6 on miosis induced by topical administration of sarin and VX in the rabbit eye].
Vojnosanit Pregl. 1990 Nov-Dec;47(6):399-401.
6
Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase.探索肟类复活剂对环沙林、沙林、塔崩和VX所致失活乙酰胆碱酯酶的理化性质。
Chem Res Toxicol. 2014 Jan 21;27(1):99-110. doi: 10.1021/tx400350b. Epub 2014 Jan 9.
7
Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.新型苯氧烷基吡啶𬭩肟作为沙林和 VX 替代物抑制的乙酰胆碱酯酶的脑穿透再激活剂的疗效。
Chem Biol Interact. 2016 Nov 25;259(Pt B):154-159. doi: 10.1016/j.cbi.2016.07.004. Epub 2016 Jul 5.
8
Antidotal efficacy of pyridinium oximes and cholineacetyltransferase inhibitors against organophosphorus intoxication in rodents.吡啶肟类化合物和胆碱乙酰转移酶抑制剂对啮齿动物有机磷中毒的解毒效果。
Indian J Physiol Pharmacol. 2000 Jan;44(1):50-6.
9
Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?不同沙林和塔崩类似物与人乙酰胆碱酯酶和肟类化合物相互作用的动力学分析：是否存在构效关系？
Chem Biol Interact. 2010 Sep 6;187(1-3):215-9. doi: 10.1016/j.cbi.2010.01.035. Epub 2010 Jan 25.
10
In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers.通过二甲苯连接的双吡啶𬭩肟体外复活沙林抑制的人乙酰胆碱酯酶（AChE）。
Toxicol In Vitro. 2011 Feb;25(1):251-6. doi: 10.1016/j.tiv.2010.07.024. Epub 2010 Aug 3.

引用本文的文献

1
Evaluating risk, exposure, and detection capabilities for chemical threats in water.评估水中化学威胁的风险、暴露和检测能力。
J Toxicol Environ Health A. 2022 Aug 3;85(15):622-647. doi: 10.1080/15287394.2022.2064949. Epub 2022 Apr 30.
2
Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.正电子发射断层扫描研究有机磷化学威胁和肟类解毒剂对策。
Neurobiol Dis. 2020 Jan;133:104455. doi: 10.1016/j.nbd.2019.04.011. Epub 2019 Apr 22.
3
Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase.
乙酰胆碱酯酶和丁酰胆碱酯酶的复活和激活。
Chemistry. 2019 Apr 11;25(21):5337-5371. doi: 10.1002/chem.201805075. Epub 2019 Feb 13.
4
Kinetic analysis of oxime-assisted reactivation of human, Guinea pig, and rat acetylcholinesterase inhibited by the organophosphorus pesticide metabolite phorate oxon (PHO).肟辅助复活被有机磷农药代谢物氧乐果（PHO）抑制的人、豚鼠和大鼠乙酰胆碱酯酶的动力学分析。
Pestic Biochem Physiol. 2018 Feb;145:93-99. doi: 10.1016/j.pestbp.2018.01.009. Epub 2018 Jan 31.
5
Study of -Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.用于老化乙酰胆碱酯酶再烷基化的醌甲基化物前体的研究。
ACS Med Chem Lett. 2017 May 8;8(6):622-627. doi: 10.1021/acsmedchemlett.7b00037. eCollection 2017 Jun 8.
6
Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.新型有机磷酸酯配体O-(2-氟乙基)-O-(对硝基苯基)甲基膦酸酯：合成、水解稳定性以及胆碱酯酶抑制和复活作用的分析
Chem Res Toxicol. 2016 Nov 21;29(11):1810-1817. doi: 10.1021/acs.chemrestox.6b00160. Epub 2016 Oct 17.
7
Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors.人类乙酰胆碱酯酶和丁酰胆碱酯酶的天然遗传变异及其对胆碱酯酶抑制剂毒性风险的潜在影响。
Chem Res Toxicol. 2016 Sep 19;29(9):1381-92. doi: 10.1021/acs.chemrestox.6b00228. Epub 2016 Aug 31.
8
Effects of repeated low-dose exposure of the nerve agent VX on monoamine levels in different brain structures in mice.重复低剂量接触神经毒剂 VX 对小鼠不同脑区单胺类递质水平的影响。
Neurochem Res. 2014 May;39(5):911-21. doi: 10.1007/s11064-014-1286-2. Epub 2014 Mar 28.
9
Efficacy assessment of a combined anticholinergic and oxime treatment against topical sarin-induced miosis and visual impairment in rats.抗胆碱能药物与肟联合治疗对局部应用沙林诱导大鼠瞳孔缩小和视力损害的疗效评估
Br J Pharmacol. 2014 May;171(9):2364-74. doi: 10.1111/bph.12586.
10
Synthesis and anti-acetylcholinesterase properties of novel β- and γ-substituted alkoxy organophosphonates.新型β-和γ-取代烷氧基有机膦酸酯的合成及抗乙酰胆碱酯酶活性。
Bioorg Med Chem Lett. 2013 Apr 1;23(7):2048-51. doi: 10.1016/j.bmcl.2013.02.010. Epub 2013 Feb 13.