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Appl Microbiol. 1974 Jan;27(1):206-9. doi: 10.1128/am.27.1.206-209.1974.
2
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10
Hydrogen-dependent organisms from the human gingival crevice resembling Vibrio succinogenes.来自人类牙龈沟的类似于产琥珀酸弧菌的依赖氢气的微生物。
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本文引用的文献

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Cytochrome-producing anaerobic Vibrio succinogenes, sp. n.产细胞色素的厌氧琥珀酸弧菌，新种
J Bacteriol. 1961 Jun;81(6):911-7. doi: 10.1128/jb.81.6.911-917.1961.
2
Two L-asparaginases from Escherichia coli B. Their separation, purification, and antitumor activity.来自大肠杆菌B的两种L-天冬酰胺酶。它们的分离、纯化及抗肿瘤活性。
Biochemistry. 1967 Mar;6(3):721-30. doi: 10.1021/bi00855a011.
3
Purification and properties of Bacillus coagulans L-asparaginase.
Arch Biochem Biophys. 1971 Dec;147(2):744-52. doi: 10.1016/0003-9861(71)90434-6.
4
Purification and properties of an L-asparaginase from Fusarium tricinctum.来自三线镰刀菌的L-天冬酰胺酶的纯化及性质
Arch Biochem Biophys. 1971 Jan;142(1):184-9. doi: 10.1016/0003-9861(71)90274-8.
5
Requirement of succinate for the growth of Vibrio succinogenes.琥珀酸弧菌生长对琥珀酸的需求。
J Bacteriol. 1972 Feb;109(2):546-9. doi: 10.1128/jb.109.2.546-549.1972.
6
Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity.具有抗肿瘤活性的无色杆菌科谷氨酰胺酶 - 天冬酰胺酶的分离、结晶及性质
J Biol Chem. 1972 Jan 10;247(1):84-90.
7
Asparaginase and glutaminase activities of bacteria.细菌的天冬酰胺酶和谷氨酰胺酶活性
J Gen Microbiol. 1971 Dec;69(3):299-312. doi: 10.1099/00221287-69-3-299.
8
Purification and properties of L-asparaginase from Serratia marcescens.粘质沙雷氏菌L-天冬酰胺酶的纯化及性质
J Bacteriol. 1971 May;106(2):578-87. doi: 10.1128/jb.106.2.578-587.1971.
9
New procedures for purification of L-asparaginase with high yield from Escherichia coli.从大肠杆菌中高产纯化L-天冬酰胺酶的新方法。
J Bacteriol. 1968 Jun;95(6):2117-23. doi: 10.1128/jb.95.6.2117-2123.1968.
10
Factors which may influence the effectiveness of L-asparaginases as tumor inhibitors.可能影响L-天冬酰胺酶作为肿瘤抑制剂有效性的因素。
Br J Cancer. 1968 Sep;22(3):595-602. doi: 10.1038/bjc.1968.71.

瘤胃厌氧菌琥珀酸弧菌产生L-天冬酰胺酶。

L-Asparaginase production by the rumen anaerobe Vibrio succinogenes.

作者信息

Kafkewitz D, Goodman D

出版信息

Appl Microbiol. 1974 Jan;27(1):206-9. doi: 10.1128/am.27.1.206-209.1974.

DOI:10.1128/am.27.1.206-209.1974
PMID:4855647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC379995/
Abstract

The rumen anaerobe Vibrio succinogenes possesses a constitutive L-asparaginase. The amount of enzyme produced is affected by the compound supplied to the organism to generate the fumaric acid it requires as a terminal electron acceptor. When nitrate is provided as the terminal electron acceptor, the amount of enzyme produced is affected by the compound provided to satisfy the nutritional requirement of the organism for succinic acid. Specific activities of up to 8.4 IU/mg of protein in cell-free extracts have been obtained. This specific activity is higher than has been previously reported for any organism. The enzyme has an apparent K(m) of 1.7 x 10(-5) M and low activity towards L-glutamine when assayed at pH 8.5.

摘要

瘤胃厌氧菌产琥珀酸弧菌拥有一种组成型L-天冬酰胺酶。所产生的酶量受供给该生物体以生成其所需的富马酸作为末端电子受体的化合物的影响。当提供硝酸盐作为末端电子受体时，所产生的酶量受为满足该生物体对琥珀酸的营养需求而提供的化合物的影响。在无细胞提取物中已获得高达8.4 IU/mg蛋白质的比活性。该比活性高于先前报道的任何生物体。该酶在pH 8.5下测定时的表观K(m)为1.7×10(-5) M，对L-谷氨酰胺的活性较低。