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Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.

作者信息

Tidd D M, Paterson A R

出版信息

Cancer Res. 1974 Apr;34(4):733-7.

PMID:4856045
Abstract
摘要

相似文献

1
Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.
Cancer Res. 1974 Apr;34(4):733-7.
2
A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.6-巯基嘌呤延迟性细胞毒性反应的生化机制。
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Effect of methylthioinosine on nucleotide concentrations in L5178Y cells.甲硫肌苷对L5178Y细胞中核苷酸浓度的影响。
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Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.6-硫鸟嘌呤、6-巯基嘌呤和8-氮鸟嘌呤的作用机制。
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Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.硫嘌呤甲基转移酶对巯嘌呤和硫鸟嘌呤在人白血病细胞中作用的不同贡献。
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Purine nucleotide metabolism and nucleotide pool sizes in synchronized lymphoma L5178Y cells.同步化淋巴瘤L5178Y细胞中的嘌呤核苷酸代谢与核苷酸库大小
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Murine lymphoma L5178Y cells resistant to purine antagonists: differences in cross-resistance to thioguanine-platinum(II) and selenoguanine-platinum(II).
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Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.6-硫鸟嘌呤与6-（甲硫基）嘌呤核糖核苷在肉瘤180细胞中协同作用的生化机制。
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Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide.6-巯基嘌呤的延迟细胞毒性与因6-硫鸟嘌呤以6-硫鸟嘌呤核苷酸形式掺入DNA而导致的DNA损伤所引起的有丝分裂死亡相符。
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10
Effect of sulfur containing purine nucleosides on immunological reaction in mice. I. Immunosuppressive effect of several alkylthio, aralkylthio and thiocyanatopurines and their ribonucleosides.含硫嘌呤核苷对小鼠免疫反应的影响。I. 几种烷硫基、芳烷硫基和硫氰基嘌呤及其核糖核苷的免疫抑制作用。
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MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia.在小儿 B 淋巴细胞白血病缓解期 MSH6 杂合性缺失导致巯嘌呤耐药的发生。
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Molecular dynamics simulation of a human thiopurine S-methyltransferase complexed with 6-mercaptopurine model.人硫嘌呤S-甲基转移酶与6-巯基嘌呤模型复合物的分子动力学模拟
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Structural basis of allele variation of human thiopurine-S-methyltransferase.人类硫嘌呤 - S - 甲基转移酶等位基因变异的结构基础
Proteins. 2007 Apr 1;67(1):198-208. doi: 10.1002/prot.21272.
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Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease.硫唑嘌呤活性代谢物浓度在炎症性肠病中的临床意义
Gut. 2004 Aug;53(8):1123-8. doi: 10.1136/gut.2003.032896.
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Antagonism of drugs used in leukaemia therapy to the killing of human lymphoblastoid cells by steroid.白血病治疗药物对类固醇杀伤人类淋巴母细胞的拮抗作用。
Br J Cancer. 1981 Sep;44(3):467-71. doi: 10.1038/bjc.1981.208.
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Synchronisation by hydroxyurea does not affect the sensitivity of CEM-C7 lymphoblasts to glucocorticoids.羟基脲同步化处理不会影响CEM-C7淋巴母细胞对糖皮质激素的敏感性。
Br J Cancer. 1984 Mar;49(3):363-6. doi: 10.1038/bjc.1984.57.
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The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaptopurine-sensitive and -resistant cell culture lines.6-巯基嘌呤核苷酸衍生物对6-巯基嘌呤敏感和耐药细胞系生长及存活的影响。
Br J Cancer. 1985 Apr;51(4):505-14. doi: 10.1038/bjc.1985.73.
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6-mercaptopurine: high-dose 24-h infusions in goats.6-巯基嘌呤：山羊高剂量24小时输注
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