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A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.

作者信息

Tidd D M, Paterson A R

出版信息

Cancer Res. 1974 Apr;34(4):738-46.

PMID:4856046
Abstract
摘要

相似文献

1
A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.6-巯基嘌呤延迟性细胞毒性反应的生化机制。
Cancer Res. 1974 Apr;34(4):738-46.
2
Distinction between inhibition of purine nucleotide synthesis and the delayed cytotoxic reaction of 6-mercaptopurine.
Cancer Res. 1974 Apr;34(4):733-7.
3
Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.6-硫鸟嘌呤与6-（甲硫基）嘌呤核糖核苷在肉瘤180细胞中协同作用的生化机制。
Cancer Res. 1972 Oct;32(10):2034-41.
4
Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide.6-巯基嘌呤的延迟细胞毒性与因6-硫鸟嘌呤以6-硫鸟嘌呤核苷酸形式掺入DNA而导致的DNA损伤所引起的有丝分裂死亡相符。
J Exp Clin Cancer Res. 1999 Sep;18(3):417-24.
5
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.暴露于甲氨蝶呤或5-氟尿嘧啶后小鼠5178Y淋巴瘤细胞中脱氧核糖核苷三磷酸库的变化。
Cancer Res. 1973 Dec;33(12):3086-90.
6
[Antimetabolites in the therapy of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. I].[抗代谢物在人类急性白血病治疗中的应用。药物作用机制及细胞对药物反应的调节因素。I]
Clin Ter. 1974 Apr 15;69(1):67-86.
7
Deoxythioguanosine and thioguanine.脱氧硫代鸟苷和硫代鸟嘌呤。
Clin Pharmacol Ther. 1973 Nov-Dec;14(6):966-9. doi: 10.1002/cpt1973146966.
8
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.6-硫鸟嘌呤、6-巯基嘌呤和8-氮鸟嘌呤的作用机制。
Cancer Res. 1975 Oct;35(10):2872-8.
9
Effect of methotrexate on deoxyribonucleotide pools and DNA synthesis in human lymphocytic cells.甲氨蝶呤对人淋巴细胞中脱氧核糖核苷酸库及DNA合成的影响。
Cancer Res. 1974 Aug;34(8):1883-8.
10
[Antimetabolites in the treatment of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. II].
Clin Ter. 1974 Apr 30;69(2):153-76.

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Low-Dose Azathioprine in Combination with Allopurinol: The Past, Present and Future of This Useful Duo.低剂量巯嘌呤联合别嘌醇：这一有效组合的过去、现在与未来。
Dig Dis Sci. 2022 Dec;67(12):5382-5391. doi: 10.1007/s10620-022-07719-x. Epub 2022 Oct 15.
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Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium.基于基因组的发现和全合成 janustatins，一种来自植物相关细菌的强效细胞毒素。
Nat Chem. 2022 Oct;14(10):1193-1201. doi: 10.1038/s41557-022-01020-0. Epub 2022 Sep 5.
3
Clinical Considerations Regarding the Use of Thiopurines in Older Patients with Inflammatory Bowel Disease.
老年炎症性肠病患者使用硫唑嘌呤时的临床注意事项。
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4
New methods to assess 6-thiopurine toxicity and expanding its therapeutic application to pancreatic cancer small molecule potentiators.评估6-硫代嘌呤毒性并将其治疗应用扩展至胰腺癌的新方法——小分子增强剂。
Medchemcomm. 2019 Mar 18;10(5):717-725. doi: 10.1039/c9md00010k. eCollection 2019 May 1.
5
Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy.重新设计抗白血病药物6-硫嘌呤的努力：在保持疗效的同时降低毒副作用。
Medchemcomm. 2018 Dec 20;10(1):169-179. doi: 10.1039/c8md00463c. eCollection 2019 Jan 1.
6
Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells - Effects on gene expression levels and thiopurine metabolism.6-巯基嘌呤与别嘌呤醇联合处理HepG2和HEK293细胞——对基因表达水平和硫嘌呤代谢的影响
PLoS One. 2017 Mar 9;12(3):e0173825. doi: 10.1371/journal.pone.0173825. eCollection 2017.
7
Pharmacology and Optimization of Thiopurines and Methotrexate in Inflammatory Bowel Disease.炎症性肠病中硫嘌呤和甲氨蝶呤的药理学及优化
Clin Pharmacokinet. 2016 Mar;55(3):257-74. doi: 10.1007/s40262-015-0316-9.
8
Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment.综述文章：用于治疗炎症性肠病的药物的药代动力学和药效学
Eur J Clin Pharmacol. 2015 Jul;71(7):773-99. doi: 10.1007/s00228-015-1862-7. Epub 2015 May 27.
9
Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003.硫嘌呤甲基转移酶与英国急性淋巴细胞白血病试验ALL2003中的治疗结果
Br J Haematol. 2015 Aug;170(4):550-8. doi: 10.1111/bjh.13469. Epub 2015 May 5.
10
Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.儿童淋巴细胞白血病中硫嘌呤剂量强度与治疗结果：硫嘌呤甲基转移酶药物遗传学的影响
Br J Haematol. 2015 Apr;169(2):228-40. doi: 10.1111/bjh.13240. Epub 2014 Nov 29.