Andrieu J L, Vial C, Font B, Goldschmidt D, Lievre M, Faucon G
Arch Int Pharmacodyn Ther. 1979 Feb;237(2):330-42.
Theophylline-induced variations of cardiac metabolism have been investigated by determining concentrations of various energetic substrates and of high-energy phosphates in myocardial tissue, the repeated sampling of myocardium being made possible by an extracorporal circulation system. When administered in therapeutic, or even slightly higher doses, theophylline does not modify triglyceride, glycerol and free fatty acid content or phosphocreatine and ATP content in subepicardial and subendocardial layers, but it does lower glycogen and raise lactate concentration. Consequently, the changes in anaerobic glycolysis due to myocardial ischemia may be enhanced if, as is probably the case, theophylline fails to restore the supply of oxygen.
通过测定心肌组织中各种高能底物和高能磷酸盐的浓度，研究了茶碱引起的心脏代谢变化，体外循环系统使重复采集心肌成为可能。当以治疗剂量甚至略高剂量给药时，茶碱不会改变心外膜下和心内膜下层的甘油三酯、甘油和游离脂肪酸含量或磷酸肌酸和ATP含量，但会降低糖原含量并提高乳酸浓度。因此，如果茶碱可能无法恢复氧气供应，那么心肌缺血引起的无氧糖酵解变化可能会增强。
