• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine.

作者信息

Fahn S

出版信息

Neurology. 1974 May;24(5):431-41. doi: 10.1212/wnl.24.5.431.

DOI:10.1212/wnl.24.5.431
PMID:4857104
Abstract
摘要

相似文献

1
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine.帕金森病左旋多巴治疗中的“开-关”现象。临床与药理学相关性及肌肉注射维生素B6的作用
Neurology. 1974 May;24(5):431-41. doi: 10.1212/wnl.24.5.431.
2
Levodopa, carbidopa, and pyridoxine in Parkinson disease. Metabolic interactions.左旋多巴、卡比多巴和吡哆醇在帕金森病中的代谢相互作用
Arch Neurol. 1974 Jun;30(6):444-7. doi: 10.1001/archneur.1974.00490360020005.
3
Metabolic interactions of pyridoxine, levodopa, and carbidopa in Parkinson's disease.帕金森病中吡哆醇、左旋多巴和卡比多巴的代谢相互作用。
Trans Am Neurol Assoc. 1973;98:241-5.
4
L-Dopa, B 6 , and alpha-methyldopa hydrazine.左旋多巴、维生素B6和α-甲基多巴肼。
Confin Neurol. 1973;35(3):186-92.
5
MK 486 and levodopa in treatment of Parkinsonism.
Dis Nerv Syst. 1973 Apr-May;34(4):167-71.
6
Ro 4-4602 and levodopa in the treatment of Parkinsonism.
Neurology. 1974 May;24(5):482-6. doi: 10.1212/wnl.24.5.482.
7
Parkinsonism-dementia of Guam: treatment with levodopa and L-alpha-methyldopahydrazine.
Neurology. 1974 Mar;24(3):263-5. doi: 10.1212/wnl.24.3.263.
8
Levodopa in Parkinsonism: potentiation of central effects with a peripheral inhibitor.左旋多巴治疗帕金森病:外周抑制剂增强中枢效应
N Engl J Med. 1972 Jan 6;286(1):8-14. doi: 10.1056/NEJM197201062860102.
9
Levodopa combined with MK 486 (L-alpha methyldopahydrazine)--a peripheral decarboxylase inhibitor in Parkinson's disease.左旋多巴与MK 486(L-α-甲基多巴肼)联合应用——一种帕金森病外周脱羧酶抑制剂。
Med J Aust. 1974 Mar 23;1(12):429-32.
10
Plasma concentration of levodopa in Parkinsonism before and after inhibition of peripheral decarboxylase.
J Neurol Sci. 1972 Sep;17(1):45-51. doi: 10.1016/0022-510x(72)90021-4.

引用本文的文献

1
Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.帕金森病患者无意识运动抑制受损与多巴胺缺失的区域选择性有关。
Neurosci Biobehav Rev. 2024 Jul;162:105719. doi: 10.1016/j.neubiorev.2024.105719. Epub 2024 May 17.
2
Metabolite profiling of foslevodopa/foscarbidopa in plasma of healthy human participants by LC-HRMS indicates no major differences compared to administration of levodopa/carbidopa intestinal gel.采用 LC-HRMS 对健康人体参与者血浆中的 foslevodopa/foscarbidopa 进行代谢物分析,结果表明与给予左旋多巴/卡比多巴肠凝胶相比无明显差异。
Pharmacol Res Perspect. 2024 Apr;12(2):e1190. doi: 10.1002/prp2.1190.
3
Role of dopamine agonists in Parkinson's disease therapy.
多巴胺激动剂在帕金森病治疗中的作用。
J Neural Transm (Vienna). 2023 Jun;130(6):863-873. doi: 10.1007/s00702-023-02647-0. Epub 2023 May 11.
4
Why do 'OFF' periods still occur during continuous drug delivery in Parkinson's disease?为什么在帕金森病的持续药物输送中仍会出现“关闭”期?
Transl Neurodegener. 2022 Oct 13;11(1):43. doi: 10.1186/s40035-022-00317-x.
5
Parkinson's disease, dopaminergic drugs and the plant world.帕金森病、多巴胺能药物与植物界
Front Pharmacol. 2022 Sep 5;13:970714. doi: 10.3389/fphar.2022.970714. eCollection 2022.
6
How I treat Parkinson's disease.我对帕金森病的治疗方法。
Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):94-104. doi: 10.1590/0004-282X-ANP-2022-S126.
7
How to Optimize the Effectiveness and Safety of Parkinson's Disease Therapy? - A Systematic Review of Drugs Interactions with Food and Dietary Supplements.如何优化帕金森病治疗的效果和安全性?——药物与食物和膳食补充剂相互作用的系统评价。
Curr Neuropharmacol. 2022;20(7):1427-1447. doi: 10.2174/1570159X19666211116142806.
8
in Parkinson disease: A double-blind, randomized, controlled, crossover study.帕金森病:一项双盲、随机、对照、交叉研究。
Neurology. 2017 Aug 1;89(5):432-438. doi: 10.1212/WNL.0000000000004175. Epub 2017 Jul 5.
9
Development of new levodopa treatment strategies in Parkinson's disease-from bedside to bench to bedside.帕金森病新左旋多巴治疗策略的发展——从床边到实验室再到床边
Ups J Med Sci. 2017 Jun;122(2):71-77. doi: 10.1080/03009734.2017.1285374. Epub 2017 Mar 3.
10
Gene-based therapy of Parkinson's Disease: Translation from animal model to human clinical trial employing convection enhanced delivery.帕金森病的基因治疗:从动物模型到采用对流增强递送的人体临床试验的转化
Ann Neurosci. 2012 Jul;19(3):133-46. doi: 10.5214/ans.0972.7531.190310.