一氟乙酸对大鼠肾脏氢离子排泄的影响。

Effect of monofluoroacetate on renal H+ excretion in the rat.

作者信息

Simonnet H, Gauthier C, Pellet M V

出版信息

Arch Int Pharmacodyn Ther. 1979 May;239(1):148-54.

Abstract

In order to investigate the effect of monofluoroacetate (MFA) on renal H+ excretion, anesthetized rats under mannitol diuresis were given intraperitoneally MFA and some of the acido-basic status parameters were determined. Urinary pH and pCO2 did not change after MFA administration, while urinary flow rate increased. MFA induced a decrease in H+ net excretion and in ammonia excretion. Titratable acidity did not change significantly within the experiment.

摘要

为了研究一氟乙酸（MFA）对肾脏氢离子排泄的影响，对处于甘露醇利尿状态下的麻醉大鼠腹腔注射MFA，并测定一些酸碱状态参数。注射MFA后，尿pH值和pCO2没有变化，而尿流率增加。MFA导致氢离子净排泄量和氨排泄量减少。在实验过程中，可滴定酸度没有明显变化。