Dikshteĭn E A, Vasilenko I V, Shevchenko N I, Merezhko V A
Arkh Patol. 1979;41(7):25-32.
The intensity of differentiation of adenocarcinoma and non-differentiated cancer cells was studied histochemically and electron microscopically. A higher ratio of nucleus volume to cytoplasm volume and nucleus nuclei acids to cytoplasm RNA, low secretory activity in adenocarcinoma cells as compared to nondifferentiated cancers were found. Adenocarcinomas were shown to have a higher activity of NADP-dependent dehydrogenases, more numerous free ribosomes as compared to nondifferentiated carcinoma. This suggests a lower degree of cell differentiation and high proliferative activity in adenocarcinomas than in nondifferentiated carcinoma. Differences in the intensity of cell and tissue differentiation in adenocarcinomas and nondifferentiated carcinoma and due to differences in their histogenesis and must be taken into account in evaluations of the prognosis.
采用组织化学和电子显微镜方法研究了腺癌细胞与未分化癌细胞的分化程度。结果发现，腺癌细胞的核体积与细胞质体积之比、细胞核核酸与细胞质RNA之比更高，与未分化癌相比，腺癌细胞的分泌活性较低。与未分化癌相比，腺癌显示出更高的NADP依赖性脱氢酶活性和更多的游离核糖体。这表明腺癌的细胞分化程度低于未分化癌，增殖活性更高。腺癌与未分化癌在细胞和组织分化强度上的差异，归因于它们组织发生的差异，在评估预后时必须予以考虑。
