Verbenko E V, Shibaeva S M, Khlebnikova S P
Arkh Patol. 1979;41(8):36-40.
Histochemical study of fat in the adipocytes of the subcutaneous adipose tissue in 12 patients with erythema nodosum revealed an upset balance of the oxidation process in fat and accumulation of free peroxide and aldehyde groups. The imbalance in the oxidation processes in the adipocytes in the areas of hemorrhages is apparently associated with haemin catalysis. The accumulation of incomplete oxidation products in lesions is believed to be a local process caused by pathological changes in the blood vessels. The toxicity of the products of peroxide oxidation should be taken into consideration in treating patients with erythema nodosum.
对12例结节性红斑患者皮下脂肪组织中脂肪细胞进行的组织化学研究显示，脂肪氧化过程平衡失调，游离过氧化物和醛基蓄积。出血部位脂肪细胞氧化过程的失衡显然与血红素催化有关。病变中不完全氧化产物的蓄积被认为是由血管病理变化引起的局部过程。在治疗结节性红斑患者时应考虑过氧化物氧化产物的毒性。
