Honma T, Bang D, Saito T, Nakagawa S, Ueki H, Lee S
Department of Pharmacology, Kawasaki Medical School, Kurashiki, Japan.
Arch Dermatol. 1987 Dec;123(12):1650-4.
In this study, biopsy specimens from 18 patients with Behçet's syndrome were examined by electron microscopy with particular attention to the appearance of the lymphocyte-macrophage infiltrate into the interlobules of subcutaneous fat in erythema nodosum-like lesions. Electron microscopic evaluation revealed vacuolization changes of fat cells with detachment of their cell membrane from the basal lamina that permitted lymphocytes and macrophages to enter into this developed space. We believe that the detachment of fat cells from the basal lamina precedes invasion by lymphocytes which, in turn, attracts macrophages into the space. This eventually leads to fat-cell lysis accompanied by activation of macrophages, which causes further inflammation, completing the picture of panniculitis in the erythema nodosum-like lesions in Behçet's syndrome.
在本研究中，对18例白塞病患者的活检标本进行了电子显微镜检查，特别关注了结节性红斑样病变中淋巴细胞 - 巨噬细胞浸润至皮下脂肪小叶间的情况。电子显微镜评估显示脂肪细胞出现空泡化变化，其细胞膜与基膜分离，使得淋巴细胞和巨噬细胞能够进入这个形成的间隙。我们认为脂肪细胞与基膜分离先于淋巴细胞的浸润，而淋巴细胞浸润又吸引巨噬细胞进入该间隙。这最终导致脂肪细胞溶解，并伴有巨噬细胞活化，进而引发进一步炎症，形成白塞病结节性红斑样病变中的脂膜炎表现。
