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Synthesis of oxytocin and related diastereomers deuterated in the half-cystine positions. Comparison of solid-phase and solution methods.

作者信息

Spatola A F, Cornelius D A, Hruby V J, Blomquist A T

出版信息

J Org Chem. 1974 Jul 26;39(15):2207-12. doi: 10.1021/jo00929a014.

DOI:10.1021/jo00929a014
PMID:4859518
Abstract
摘要

相似文献

1
Synthesis of oxytocin and related diastereomers deuterated in the half-cystine positions. Comparison of solid-phase and solution methods.在半胱氨酸位置氘代的催产素及相关非对映异构体的合成。固相法与溶液法的比较。
J Org Chem. 1974 Jul 26;39(15):2207-12. doi: 10.1021/jo00929a014.
2
Synthesis of specifically deuterated S-benzylcysteines and of oxytocin and related diastereomers deuterated in the half-cystine positions.在半胱氨酸位置进行特定氘代的S-苄基半胱氨酸以及催产素和相关非对映异构体的合成。
J Org Chem. 1976 Apr 16;41(8):1353-8. doi: 10.1021/jo00870a014.
3
Synthesis and some pharmacological properties of [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine]oxytocin (hydroxy [4-thr]oxytocin), a peptide with strikingly high oxytocic potency and of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin (hydroxy-oxytocin).
J Med Chem. 1976 Mar;19(3):376-80. doi: 10.1021/jm00225a007.
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Further studies of the role of the asparagine residue in oxytocin. Synthesis and biological properties of (5- , -diaminobutyric acid)oxytocin.关于催产素中天冬酰胺残基作用的进一步研究。(5-,-二氨基丁酸)催产素的合成及生物学特性。
J Med Chem. 1972 Feb;15(2):126-8. doi: 10.1021/jm00272a002.
5
Solid-phase synthesis of (2-isoleucine, 4-leucine) oxytocin and (2-phenylalanine, 4-leucine) oxytocin and some their pharmacological properties.(2-异亮氨酸,4-亮氨酸)催产素和(2-苯丙氨酸,4-亮氨酸)催产素的固相合成及其某些药理特性
J Med Chem. 1973 Jun;16(6):624-9. doi: 10.1021/jm00264a010.
6
Synthesis of (1,6-alpha,alpha'-diaminosuberic acid)oxytocin ('dicarba-oxytocin').
Helv Chim Acta. 1974;57(5):1253-9. doi: 10.1002/hlca.19740570502.
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Synthesis of (1-(L-2-hydroxy-3-mercaptopropanoic acid))oxytocin, a highly potent analogue of oxytocin.催产素的一种高效类似物(1-(L-2-羟基-3-巯基丙酸))催产素的合成。
J Chem Soc Perkin 1. 1972;15:1946-50. doi: 10.1039/p19720001946.
8
Crystalline deamino-dicarba-oxytocin. Preparation and some pharmacological properties.
Mol Pharmacol. 1970 Sep;6(5):474-80.
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Solid phase synthesis of (3,4-dileucine)-oxytocin and a study of some of its pharmacological properties.(3,4-二亮氨酸)-催产素的固相合成及其部分药理性质研究
J Med Chem. 1972 Jan;15(1):11-2. doi: 10.1021/jm00271a004.
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Solid-phase synthesis of (4-threonine)-oxytocin. A more potent and specific oxytocic agent than oxytocin.(4-苏氨酸)-催产素的固相合成。一种比催产素更有效且更具特异性的催产剂。
Biochemistry. 1970 Sep 29;9(20):3925-30. doi: 10.1021/bi00822a010.