Mead R J, Oliver A J, King D R
Aust J Biol Sci. 1979 Feb;32(1):15-26.
The brush-tailed possum (T. vulpecula) from Western Australia was found to be nearly 150 times more resistant to fluoroacetate intoxication in vivo than the same species from South Australia. Acetone powder preparations from the liver of animals from both populations showed similar abilities to convert fluoroacetate into fluorocitrate. Aconitate hydratase activity in liver preparations from both Western Australian and South Australian animals was similarly and competitively inhibited by fluorocitrate. Both animals were capable of defluorinating fluoroacetate at similar rates by a glutathione-dependent enzymic mechanism resulting in the formation of free fluoride ion and S-carboxymethylcysteine. Glutathione was also capable of partial protection against the toxic effects of fluoroacetate in vitro by a further unelucidated mechanism.
研究发现，来自西澳大利亚的帚尾袋貂（T. vulpecula）在体内对氟乙酸盐中毒的抵抗力比来自南澳大利亚的同物种袋貂强近150倍。来自这两个种群动物肝脏的丙酮粉制剂将氟乙酸盐转化为氟柠檬酸盐的能力相似。西澳大利亚和南澳大利亚动物肝脏制剂中的乌头酸水合酶活性受到氟柠檬酸盐的相似竞争性抑制。两种动物都能够通过谷胱甘肽依赖性酶机制以相似的速率使氟乙酸盐脱氟，从而形成游离氟离子和S-羧甲基半胱氨酸。谷胱甘肽还能够通过另一种未阐明的机制在体外对氟乙酸盐的毒性作用起到部分保护作用。
