氟乙酸盐和氟柠檬酸盐：作用机制
Fluoroacetate and fluorocitrate: mechanism of action.
作者信息
Clarke D D
机构信息
Department of Chemistry, Fordham University, Bronx, NY 10458.
出版信息
Neurochem Res. 1991 Sep;16(9):1055-8. doi: 10.1007/BF00965850.
PMID:1784332
Abstract
The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.
摘要
根据该领域的最新研究成果，对彼得斯提出的致死合成概念进行了综述。有人认为，氟柠檬酸是乌头酸酶的一种“自杀性”底物，而不是最初认为的竞争性抑制剂。还讨论了利用这些物质研究神经胶质细胞与神经元关系的情况。
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