正常细胞条件培养基对囊性纤维化成纤维细胞中Tamm-Horsfall糖蛋白诱导碱性磷酸酶的抑制作用。

Inhibition of Tamm-Horsfall glycoprotein induction of alkaline phosphatase in cystic fibrosis fibroblasts by medium conditioned by normal cells.

作者信息

Carey W F, Hösli P

出版信息

Aust J Exp Biol Med Sci. 1979 Apr;57(2):225-30. doi: 10.1038/icb.1979.23.

DOI:10.1038/icb.1979.23

Abstract

It is confirmed that the level of alkaline phosphatase in fibroblasts derived from cystic fibrosis patients can be induced many-fold by growing the cells in the presence of Tamm-Horsfall glycoprotein. It is further shown that normal fibroblasts produce a "CF corrective factor" which markedly inhibits this phenomenon. These observations support a previous hypothesis on the nature of the metabolic defect in cystic fibrosis.

摘要

已证实，通过在存在Tamm-Horsfall糖蛋白的情况下培养细胞，囊性纤维化患者来源的成纤维细胞中的碱性磷酸酶水平可被诱导增加许多倍。进一步表明，正常成纤维细胞产生一种“CF校正因子”，该因子可显著抑制这种现象。这些观察结果支持了先前关于囊性纤维化代谢缺陷本质的假说。