Bourgoin S, Héry F, Ternaux J P, Hanson M
Psychopharmacol Commun. 1975;1(2):209-16.
Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. As a result, in vivo treatment with one of these compounds (chlordiazepoxide for instance) induced a significant increase in the concentration of free tryptophan in serum. These observations suggest that the high levels of both 5-hydroxyindoles and tryptophan which occurred in the rat brain after any benzodiazepine administration could be at least partly the consequence of its effect on tryptophan binding in blood.
苯二氮䓬类药物（地西泮、奥沙西泮、氯氮卓）竞争性抑制色氨酸与大鼠血清白蛋白的结合。因此，用这些化合物之一（例如氯氮卓）进行体内治疗会导致血清中游离色氨酸浓度显著升高。这些观察结果表明，给予任何苯二氮䓬类药物后大鼠脑中出现的5-羟吲哚和色氨酸水平升高，至少部分可能是其对血液中色氨酸结合作用的结果。
