Valzelli L, Kostowski W, Bernasconi S, Sala A
Pol J Pharmacol Pharm. 1981 Jan-Feb;33(1):37-42.
Chloro-N-desmethyldiazepam (CDD) significantly reduced plasma tryptophan (TRY) and increased brain TRY in mice and rats. Quipazine did not change TRY levels in mouse plasma and brain but it respectively reduced and increased these two parameters in rats, to almost the same extent as CDD. Metergoline, an antagonist of serotonergic receptors, decreased blood TRY in both mice and rats but failed to change brain TRY. CDD significantly but slightly increased brain serotonin in rats. This effect was blocked by metergoline.
氯去甲安定（CDD）可显著降低小鼠和大鼠血浆中的色氨酸（TRY）水平，并增加其脑内TRY水平。喹哌嗪对小鼠血浆和脑内的TRY水平无影响，但对大鼠血浆和脑内的TRY水平分别有降低和增加作用，且作用程度与CDD几乎相同。麦角新碱是一种血清素能受体拮抗剂，可降低小鼠和大鼠血液中的TRY水平，但对脑内TRY水平无影响。CDD可显著但轻微增加大鼠脑内血清素水平，这一作用可被麦角新碱阻断。
