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肾脏刷状缘膜囊泡中的牛磺酸转运

Taurine transport in renal brush-border-membrane vesicles.

作者信息

Rozen R, Tenenhouse H S, Scriver C R

出版信息

Biochem J. 1979 Apr 15;180(1):245-8. doi: 10.1042/bj1800245.

DOI:10.1042/bj1800245
PMID:486101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161041/
Abstract

Taurine transport in isolated brush-border-membrane vesicles from rat kidney is concentrative and it is driven by the Na+ gradient and transmembrane potential difference; binding is not a significant component of net uptake. The Na+-dependent component of net uptake is saturable with an apparent Km of 17 microM. The taurine-transport mechanism is selective for beta-amino compounds.

摘要

从大鼠肾脏分离的刷状缘膜囊泡中的牛磺酸转运是浓缩性的，由Na+梯度和跨膜电位差驱动；结合不是净摄取的重要组成部分。净摄取的Na+依赖性成分是可饱和的，表观Km为17 microM。牛磺酸转运机制对β-氨基化合物具有选择性。

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Urinary amino-acids in mice of different genotypes.不同基因型小鼠的尿氨基酸
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4
Uptake and metabolism of beta-alanine and L-carnosine by rat tissues in vitro: role in nutrition.大鼠组织对β-丙氨酸和L-肌肽的体外摄取与代谢：在营养中的作用
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Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice.通过对高牛磺酸尿症小鼠进行体内和体外平行研究，确定牛磺酸跨上皮转运中膜缺陷的定位。
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6
The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.肾刷状缘膜中D-葡萄糖的钠梯度依赖性转运。
J Biol Chem. 1975 Aug 10;250(15):6032-9.
7
Renal tubular reabsorption of taurine, gamma-aminobutyric acid (GABA) and beta-alanine studied by continuous microperfusion.通过连续微量灌注研究牛磺酸、γ-氨基丁酸（GABA）和β-丙氨酸的肾小管重吸收。
Pflugers Arch. 1976 Dec 28;367(2):123-8. doi: 10.1007/BF00585147.
8
The defect in transcellular transport of phosphate in the nephron is located in brush-border membranes in X-linked hypophosphatemia (Hyp mouse model).在X连锁低磷血症（Hyp小鼠模型）中，肾单位中磷酸盐跨细胞转运的缺陷位于刷状缘膜。
Can J Biochem. 1978 Jun;56(6):640-6. doi: 10.1139/o78-096.
9
The role of brush border enzymes in tubular reabsorption of disaccharides: a microperfusion study in rat kidney.刷状缘酶在二糖肾小管重吸收中的作用：大鼠肾脏的微灌注研究
Pflugers Arch. 1977 Oct 19;371(1-2):141-5. doi: 10.1007/BF00580782.
10
Adrenergic stimulation of taurine transport by the heart.心脏对牛磺酸转运的肾上腺素能刺激。
Science. 1977 Oct 28;198(4315):409-11. doi: 10.1126/science.198879.