肾脏刷状缘膜囊泡中的牛磺酸转运
Taurine transport in renal brush-border-membrane vesicles.
作者信息
Rozen R, Tenenhouse H S, Scriver C R
出版信息
Biochem J. 1979 Apr 15;180(1):245-8. doi: 10.1042/bj1800245.
Abstract
Taurine transport in isolated brush-border-membrane vesicles from rat kidney is concentrative and it is driven by the Na+ gradient and transmembrane potential difference; binding is not a significant component of net uptake. The Na+-dependent component of net uptake is saturable with an apparent Km of 17 microM. The taurine-transport mechanism is selective for beta-amino compounds.
摘要
从大鼠肾脏分离的刷状缘膜囊泡中的牛磺酸转运是浓缩性的，由Na+梯度和跨膜电位差驱动；结合不是净摄取的重要组成部分。净摄取的Na+依赖性成分是可饱和的，表观Km为17 microM。牛磺酸转运机制对β-氨基化合物具有选择性。
相似文献
1
Taurine transport in renal brush-border-membrane vesicles.肾脏刷状缘膜囊泡中的牛磺酸转运
Biochem J. 1979 Apr 15;180(1):245-8. doi: 10.1042/bj1800245.
2
A gamma-aminobutyric acid-specific transport mechanism in mammalian kidney.哺乳动物肾脏中的一种γ-氨基丁酸特异性转运机制。
Biochim Biophys Acta. 1985 Aug 8;818(1):45-54. doi: 10.1016/0005-2736(85)90136-1.
3
Biotin uptake mechanisms in brush-border and basolateral membrane vesicles isolated from rabbit kidney cortex.从兔肾皮质分离的刷状缘膜囊泡和基底外侧膜囊泡中的生物素摄取机制。
Biochim Biophys Acta. 1986 Apr 25;856(3):471-81. doi: 10.1016/0005-2736(86)90138-0.
4
Taurine transport by rabbit kidney brush-border membranes: coupling to sodium, chloride, and the membrane potential.兔肾刷状缘膜对牛磺酸的转运：与钠、氯及膜电位的偶联
J Membr Biol. 1988 May;102(2):131-9. doi: 10.1007/BF01870451.
5
Sulphate-ion/sodium-ion co-transport by brush-border membrane vesicles isolated from rat kidney cortex.从大鼠肾皮质分离的刷状缘膜囊泡对硫酸根离子/钠离子的协同转运
Biochem J. 1979 Jul 15;182(1):223-9. doi: 10.1042/bj1820223.
6
Cystine uptake by rat renal brush-border vesicles.大鼠肾刷状缘小泡对胱氨酸的摄取。
Biochem J. 1981 Feb 15;194(2):443-9. doi: 10.1042/bj1940443.
7
Increased Na+-taurine symporter in rat renal brush border membranes: preformed or newly synthesized?大鼠肾刷状缘膜中钠-牛磺酸同向转运体增加：是预先存在的还是新合成的？
FASEB J. 1989 Jul;3(9):2081-5. doi: 10.1096/fasebj.3.9.2744305.
8
Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from the renal outer cortex.兔肾外皮质刷状缘和基底外侧质膜囊泡中钠依赖性和非钠依赖性核苷转运系统的特性
Biochem J. 1989 Nov 15;264(1):223-31. doi: 10.1042/bj2640223.
9
Na+ + Cl- -gradient-driven, high-affinity, uphill transport of taurine in human placental brush-border membrane vesicles.人胎盘刷状缘膜囊泡中由Na⁺ + Cl⁻梯度驱动的、高亲和力的、牛磺酸的上坡转运。
FEBS Lett. 1988 Apr 11;231(1):263-7. doi: 10.1016/0014-5793(88)80744-0.
10
Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesicles.大鼠肾刷状缘和基底外侧膜囊泡中四乙铵的载体介导转运系统
Biochim Biophys Acta. 1984 Jun 13;773(1):113-24. doi: 10.1016/0005-2736(84)90556-x.
引用本文的文献
1
Autoradiographic localization of 3H-GABA uptake in the thyroid gland of the rat.大鼠甲状腺中³H-γ-氨基丁酸摄取的放射自显影定位
Cell Tissue Res. 1981;220(4):873-9. doi: 10.1007/BF00210468.
2
GABA transport in the rat thyroid.大鼠甲状腺中的γ-氨基丁酸转运
Naunyn Schmiedebergs Arch Pharmacol. 1981 Aug;317(1):61-6. doi: 10.1007/BF00506258.
3
Delineation of sodium-stimulated amino acid transport pathways in rabbit kidney brush border vesicles.兔肾刷状缘小泡中钠刺激氨基酸转运途径的描绘
J Membr Biol. 1982;64(1-2):113-22. doi: 10.1007/BF01870773.
4
Renal transport of taurine adapts to perturbed taurine homeostasis.牛磺酸的肾脏转运适应于紊乱的牛磺酸稳态。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):2101-5. doi: 10.1073/pnas.79.6.2101.
5
The relationship between sodium and high-affinity taurine uptake in hypothalamic crude P2 synaptosomal preparations.下丘脑粗制P2突触体制剂中钠与高亲和力牛磺酸摄取之间的关系。
Neurochem Res. 1987 Aug;12(8):705-13. doi: 10.1007/BF00970526.
6
Taurine transport by rabbit kidney brush-border membranes: coupling to sodium, chloride, and the membrane potential.兔肾刷状缘膜对牛磺酸的转运：与钠、氯及膜电位的偶联
J Membr Biol. 1988 May;102(2):131-9. doi: 10.1007/BF01870451.
7
Renal handling of taurine, L-alanine, L-glutamate and D-glucose in Opsanus tau: studies on isolated brush border membrane vesicles.豹蟾鱼中牛磺酸、L-丙氨酸、L-谷氨酸和D-葡萄糖的肾脏处理：对分离的刷状缘膜囊泡的研究
J Comp Physiol B. 1987;157(5):573-81. doi: 10.1007/BF00700977.
8
Demonstration of H+- and Na+-coupled co-transport of beta-alanine by luminal membrane vesicles of rabbit proximal tubule.兔近端小管管腔膜囊泡对β-丙氨酸的H⁺和Na⁺偶联共转运的证明。
J Physiol. 1989 Apr;411:517-28. doi: 10.1113/jphysiol.1989.sp017587.
9
Sodium-taurine cotransport in reptilian renal brush-border membrane vesicles.爬行动物肾刷状缘膜囊泡中的钠-牛磺酸共转运
Pflugers Arch. 1992 Jun;421(2-3):168-75. doi: 10.1007/BF00374824.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Urinary amino-acids in mice of different genotypes.不同基因型小鼠的尿氨基酸
Ann Eugen. 1953 Feb;17(3):165-7. doi: 10.1111/j.1469-1809.1953.tb02544.x.
3
A rapid method for the preparation of microvilli from rabbit kidney.一种从兔肾制备微绒毛的快速方法。
Biochem J. 1974 Sep;142(3):575-81. doi: 10.1042/bj1420575.
4
Uptake and metabolism of beta-alanine and L-carnosine by rat tissues in vitro: role in nutrition.大鼠组织对β-丙氨酸和L-肌肽的体外摄取与代谢：在营养中的作用
Am J Physiol. 1976 Mar;230(3):643-51. doi: 10.1152/ajplegacy.1976.230.3.643.
5
Localization of the membrane defect in transepithelial transport of taurine by parallel studies in vivo and in vitro in hypertaurinuric mice.通过对高牛磺酸尿症小鼠进行体内和体外平行研究，确定牛磺酸跨上皮转运中膜缺陷的定位。
J Clin Invest. 1976 Jan;57(1):183-93. doi: 10.1172/JCI108258.
6
The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.肾刷状缘膜中D-葡萄糖的钠梯度依赖性转运。
J Biol Chem. 1975 Aug 10;250(15):6032-9.
7
Renal tubular reabsorption of taurine, gamma-aminobutyric acid (GABA) and beta-alanine studied by continuous microperfusion.通过连续微量灌注研究牛磺酸、γ-氨基丁酸（GABA）和β-丙氨酸的肾小管重吸收。
Pflugers Arch. 1976 Dec 28;367(2):123-8. doi: 10.1007/BF00585147.
8
The defect in transcellular transport of phosphate in the nephron is located in brush-border membranes in X-linked hypophosphatemia (Hyp mouse model).在X连锁低磷血症（Hyp小鼠模型）中，肾单位中磷酸盐跨细胞转运的缺陷位于刷状缘膜。
Can J Biochem. 1978 Jun;56(6):640-6. doi: 10.1139/o78-096.
9
The role of brush border enzymes in tubular reabsorption of disaccharides: a microperfusion study in rat kidney.刷状缘酶在二糖肾小管重吸收中的作用：大鼠肾脏的微灌注研究
Pflugers Arch. 1977 Oct 19;371(1-2):141-5. doi: 10.1007/BF00580782.
10
Adrenergic stimulation of taurine transport by the heart.心脏对牛磺酸转运的肾上腺素能刺激。
Science. 1977 Oct 28;198(4315):409-11. doi: 10.1126/science.198879.
Zotero 插件