大鼠肾刷状缘小泡对胱氨酸的摄取。
Cystine uptake by rat renal brush-border vesicles.
作者信息
McNamara P D, Pepe L M, Segal S
出版信息
Biochem J. 1981 Feb 15;194(2):443-9. doi: 10.1042/bj1940443.
Abstract
Uptake of L-cystine by brush-border membrane vesicles isolated from rat renal-cortical tissue was time-dependent and occurred in the absence of cystine reduction. A significant capacity for vesicular binding of cystine was observed. The amount bound increased with time of incubation and could be displaced by thiol reagents. At early time points, cystine uptake measured the transport of cystine into the intravesicular space. Total cystine uptake was mediated by multiple transport systems, including a low-Km high-affinity component which was shared by lysine, arginine, ornithine and glutamine and on which hetero-exchange diffusion of lysine and cystine was demonstrated.
摘要
从大鼠肾皮质组织分离的刷状缘膜囊泡对L-胱氨酸的摄取呈时间依赖性，且在胱氨酸未还原的情况下发生。观察到囊泡对胱氨酸具有显著的结合能力。结合量随孵育时间增加，且可被硫醇试剂取代。在早期时间点，胱氨酸摄取测量的是胱氨酸向囊泡内空间的转运。总胱氨酸摄取由多种转运系统介导，包括一种低Km高亲和力成分，赖氨酸、精氨酸、鸟氨酸和谷氨酰胺共享该成分，并且证明了赖氨酸和胱氨酸在其上的异源交换扩散。
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