Steinmuller D
Science. 1967 Oct 6;158(3797):127-9. doi: 10.1126/science.158.3797.127.
Skin isografts from mice that were immunologically tolerant to allogeneic tissue had the ability to immunize isogeneic recipients against subsequent skin allografts. The immunizing isografts showed no gross signs of rejection themselves and appeared to be only the vehicles for transplantation antigen. It seems likely that allogeneic leukocytes derived from the spleen and bone marrow cells used to confer tolerance were contained in the skin of the tolerant mice and were transferred by the skin isografts in sufficient numbers to stimulate transplantation immunity.
来自对同种异体组织具有免疫耐受性的小鼠的皮肤同基因移植片，有能力使同基因受体对随后的皮肤同种异体移植产生免疫。具有免疫作用的同基因移植片本身没有明显的排斥迹象，似乎仅仅是移植抗原的载体。很可能用于诱导耐受性的来自脾脏和骨髓细胞的同种异体白细胞包含在耐受小鼠的皮肤中，并通过皮肤同基因移植片以足够数量进行转移，从而刺激移植免疫。
