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成年小鼠中药物诱导的跨越H-2屏障的皮肤同种异体移植耐受性。

Drug-induced tolerance for skin allografts across the H-2 barrier in adult mice.

作者信息

Floersheim G L

出版信息

Science. 1967 May 19;156(3777):951-4. doi: 10.1126/science.156.3777.951.

DOI:10.1126/science.156.3777.951
PMID:5337059
Abstract

Mice treated with methylhydrazine derivatives for 3 to 4 weeks before the transplantation showed markedly prolonged survival times for allogeneic skin grafts differing at the H-2 histocompatibility locus. Presumably permanent tolerance was induced in about 20 to 30 percent of the mice when the drug treatment was combined with a single injection of additional donor antigen. The tolerance persists without further drug treatment and is specific for donor tissue.

摘要

在移植前用甲基肼衍生物处理3至4周的小鼠，对于在H-2组织相容性位点存在差异的同种异体皮肤移植，其存活时间显著延长。当药物治疗与单次注射额外的供体抗原相结合时，大约20%至30%的小鼠可能诱导出了永久性耐受。这种耐受在不再进行药物治疗的情况下仍然持续存在，并且对供体组织具有特异性。

相似文献

1
Drug-induced tolerance for skin allografts across the H-2 barrier in adult mice.成年小鼠中药物诱导的跨越H-2屏障的皮肤同种异体移植耐受性。
Science. 1967 May 19;156(3777):951-4. doi: 10.1126/science.156.3777.951.
2
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Transplant Proc. 1971 Mar;3(1):688-92.
3
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EFFECT OF THYMUS GRAFTS, SPLEEN CELL INJECTION, AND SUBLETHAL IRRADIATION ON HOMOGRAFT TOLERANCE IN MICE.胸腺移植、脾细胞注射及亚致死剂量照射对小鼠同种移植耐受性的影响
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Induction of tolerance to skin homografts with a methylhydrazine derivative. Synergism with antilymphocytic serum and morphologic responses of the lymphoid system.用甲基肼衍生物诱导对皮肤同种移植物的耐受性。与抗淋巴细胞血清的协同作用及淋巴系统的形态学反应。
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Resistance to skin grafts induced by cell extracts in congenic strains of mice differing from the donor at various non-H-2 loci.在不同非H-2位点上与供体存在差异的同基因小鼠品系中，细胞提取物诱导的皮肤移植抗性。
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STUDIES ON IMMUNOLOGIC RECONSTITUTION OF THYMECTOMIZED MICE.胸腺切除小鼠免疫重建的研究
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Bone marrow transplantation combined with mesenchymal stem cells induces immune tolerance without cytotoxic conditioning.骨髓移植联合间充质干细胞诱导免疫耐受而无需细胞毒性预处理。
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Induction of permanent mixed chimerism and skin allograft tolerance across fully MHC-mismatched barriers by the additional myelosuppressive treatments in mice primed with allogeneic spleen cells followed by cyclophosphamide.在经同种异体脾细胞致敏并随后给予环磷酰胺处理的小鼠中，通过额外的骨髓抑制治疗诱导永久性混合嵌合体并跨越完全MHC不匹配屏障实现皮肤同种异体移植耐受。
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ACQUIRED TOLERANCE TO SKIN HOMOGRAFTS IN MICE. 3. ROLE OF IMMUNE STATUS OF HOST IN INDUCTION AND MAINTENANCE OF TOLERANCE.小鼠对皮肤同种异体移植的获得性耐受。3. 宿主免疫状态在耐受诱导和维持中的作用。
J Immunol. 1964 Jul;93:114-21.

引用本文的文献

1
[Immunological tolerance].[免疫耐受]
Klin Wochenschr. 1971 Feb 15;49(4):177-93. doi: 10.1007/BF01495980.
2
A comparative study of the effects of anti-tumour and immunosuppressive drugs on antibody-forming and erythropoietic cells.抗肿瘤和免疫抑制药物对抗体形成细胞和红细胞生成细胞作用的比较研究。
Clin Exp Immunol. 1970 Jun;6(6):861-70.
3
Suppressant effect of procarbazine and its comparison with anti-lymphocyte serum in adjuvant-induced polyarthritis in rats.丙卡巴肼在佐剂诱导的大鼠多关节炎中的抑制作用及其与抗淋巴细胞血清的比较。
Clin Exp Immunol. 1970 Feb;6(2):291-7.
4
Induction of tolerance to skin homografts with a methylhydrazine derivative. Synergism with antilymphocytic serum and morphologic responses of the lymphoid system.用甲基肼衍生物诱导对皮肤同种移植物的耐受性。与抗淋巴细胞血清的协同作用及淋巴系统的形态学反应。
Agents Actions. 1970 Mar;1(3):115-23. doi: 10.1007/BF01982396.
5
Immunosuppression and its complications.免疫抑制及其并发症。
Proc R Soc Med. 1969 Apr;62(4):411-6. doi: 10.1177/003591576906200454.