外源性血红素可恢复被烯丙异丙基乙酰胺破坏的肝细胞色素P-450的体内功能。 - Suppr

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超能文献

Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide.

作者信息

Farrell G C, Schmid R, Kunze K L, Ortiz de Montellano P R

出版信息

Biochem Biophys Res Commun. 1979 Jul 27;89(2):456-63. doi: 10.1016/0006-291x(79)90651-x.

DOI:10.1016/0006-291x(79)90651-x

PMID:486175

Abstract

摘要

相似文献

Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide.外源性血红素可恢复被烯丙异丙基乙酰胺破坏的肝细胞色素P-450的体内功能。

Biochem Biophys Res Commun. 1979 Jul 27;89(2):456-63. doi: 10.1016/0006-291x(79)90651-x.

Structural and functional reconstitution of hepatic cytochrome P-450 in vivo. Reversal of allylisopropylacetamide-mediated destruction of the hemoprotein by exogenous heme.体内肝细胞色素P-450的结构与功能重建。外源性血红素逆转烯丙基异丙基乙酰胺介导的血蛋白破坏。

J Biol Chem. 1980 Nov 10;255(21):10128-33.

Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.2-烯丙基-2-异丙基乙酰胺对内源性和外源性血红素的破坏作用：苯巴比妥可诱导的肝脏细胞色素P-450的作用。

Int J Biochem. 1978;9(12):865-9. doi: 10.1016/0020-711x(78)90061-7.

Reaction schemes for the degradation of cytochrome P-450 by allyl-iso-propylacetamide and fluroxene.烯丙基异丙基乙酰胺和氟烷降解细胞色素P - 450的反应机制。

Adv Exp Med Biol. 1981;136 Pt B:1213-20.

The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits.烯丙异丙基乙酰胺对苯巴比妥处理的家兔肝微粒体细胞色素P-450 2含量的体内和体外效应。

Biochem Biophys Res Commun. 1983 Mar 29;111(3):926-32. doi: 10.1016/0006-291x(83)91388-8.

Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: mass spectrometric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites.2-异丙基-4-戊烯酰胺和2-异丙基-4-戊烯酸甲酯对细胞色素P-450的破坏作用：辅基血红素加合物的质谱表征及环氧化物代谢产物未参与作用

Arch Biochem Biophys. 1979 Oct 15;197(2):524-33. doi: 10.1016/0003-9861(79)90276-5.

Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.用苯巴比妥和烯丙异丙基乙酰胺处理的大鼠肝脏匀浆中含血红素或钴原卟啉的细胞色素P - 450的形成。

Biochem J. 1984 Sep 1;222(2):453-62. doi: 10.1042/bj2220453.

Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.大鼠肝脏中内源性铁在烯丙基异丙基乙酰胺对血红素脂质过氧化破坏过程中的催化活性证据。

Int J Biochem. 1980;12(5-6):781-5. doi: 10.1016/0020-711x(80)90162-7.

Incorporation of exogenous heme into hepatic cytochrome P-450 in vivo.体内外源性血红素掺入肝细胞色素P-450。

J Biol Chem. 1979 Jan 10;254(1):15-7.

Allylisopropylacetamide preferentially interacts with the phenobarbital-inducible form of rat hepatic microsomal P-450.

Biochem Pharmacol. 1976 Nov 1;25(21):2415-7. doi: 10.1016/0006-2952(76)90042-3.

引用本文的文献

Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.有证据表明，在鸡胚中，肝微粒体细胞色素P - 450血红素的破坏是卟啉症致病药物诱导δ-氨基乙酰丙酸合酶的一般机制。

Biochem J. 1980 Sep 15;190(3):519-26. doi: 10.1042/bj1900519.

Biochem J. 1984 Sep 1;222(2):453-62. doi: 10.1042/bj2220453.

Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide.烯丙基异丙基乙酰胺使细胞色素P-450 N-脱甲基酶失活后，血红素介导的差异性恢复

Biochem J. 1985 Apr 1;227(1):277-86. doi: 10.1042/bj2270277.

Incorporation of haemoglobin haem into the rat hepatic haemoproteins tryptophan pyrrolase and cytochrome P-450.将血红蛋白血红素掺入大鼠肝脏血红素蛋白色氨酸吡咯酶和细胞色素P-450中。

Biochem J. 1986 Sep 15;238(3):837-46. doi: 10.1042/bj2380837.

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