硝苯地平与维拉帕米相比对房室传导的影响。心内电生理研究。
Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.
作者信息
Rowland E, Evans T, Krikler D
出版信息
Br Heart J. 1979 Aug;42(2):124-7. doi: 10.1136/hrt.42.2.124.
Abstract
Intravenous nifedipine, a powerful calcium antagonist, had no obvious effect on atrioventricular conduction when administered to 11 patients during routine intracardiac electrophysiological studies. Verapamil on the other hand showed potent antiarrhythmic properties, depressing atrioventricular nodal conduction. Nifedipine thus appears safe in patients with angina pectoris who have disorders of atrioventricular nodal conduction, and in those receiving beta-adrenergic blocking drugs. There appear to be differential effects on the slow inward channels of cardiac cells with different 'calcium antagonists'.
摘要
静脉注射硝苯地平（一种强效钙拮抗剂），在对11例患者进行常规心内电生理研究时给药，对房室传导无明显影响。另一方面，维拉帕米显示出强效抗心律失常特性，可抑制房室结传导。因此，硝苯地平对于患有房室结传导障碍的心绞痛患者以及正在接受β-肾上腺素能阻滞剂治疗的患者似乎是安全的。不同的“钙拮抗剂”对心肌细胞慢内向通道似乎有不同的作用。
相似文献
1
Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.硝苯地平与维拉帕米相比对房室传导的影响。心内电生理研究。
Br Heart J. 1979 Aug;42(2):124-7. doi: 10.1136/hrt.42.2.124.
2
Comparison of the direct effects of nifedipine and verapamil on the electrical activity of the sinoatrial and atrioventricular nodes of the rabbit heart.硝苯地平与维拉帕米对兔心脏窦房结和房室结电活动直接影响的比较。
Am Heart J. 1983 Aug;106(2):345-55. doi: 10.1016/0002-8703(83)90202-8.
3
Comparative effects of three calcium antagonists, diltiazem, verapamil and nifedipine, on the sinoatrial and atrioventricular nodes. Experimental and clinical studies.三种钙拮抗剂（地尔硫䓬、维拉帕米和硝苯地平）对窦房结和房室结的比较作用。实验与临床研究。
Circulation. 1981 May;63(5):1035-42. doi: 10.1161/01.cir.63.5.1035.
4
[Electrophysiological effects of calcium-antagonists and their use in arrhythmia].
Boll Soc Ital Cardiol. 1978(1 Suppl):60-78.
5
The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.硝苯地平对β-肾上腺素能受体阻断后犬心脏窦房结和房室结的影响。
Acta Pharmacol Toxicol (Copenh). 1978 Apr;42(4):287-91. doi: 10.1111/j.1600-0773.1978.tb02203.x.
6
Effect of nifedipine and AQ-A 39 on the sinoatrial and atrioventricular nodes of the rabbit and their antiarrhythmic action on atrioventricular nodal reentrant tachycardia.硝苯地平与AQ - A 39对兔窦房结和房室结的作用及其对房室结折返性心动过速的抗心律失常作用。
Cardiovasc Res. 1983 Mar;17(3):132-44. doi: 10.1093/cvr/17.3.132.
7
Effects of nifedipine, a potent calcium-antagonistic coronary vasodilator, on atrioventricular conduction and blood flow in the isolated atrioventricular node preparation of the dog.强效钙拮抗型冠状动脉扩张剂硝苯地平对犬离体房室结标本的房室传导及血流的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):107-12. doi: 10.1007/BF00499993.
8
Differential effects of organic slow inward current inhibitors, verapamil and nifedipine, on rate of atrioventricular rhythm and supraventricular tachycardia in the canine isolated, blood-perfused AV node preparation.有机性缓慢内向电流抑制剂维拉帕米和硝苯地平对犬离体、血液灌注房室结标本中房室节律和室上性心动过速速率的不同影响。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Jan;315(3):241-8. doi: 10.1007/BF00499841.
9
Heart rate-dependent atrioventricular nodal conduction and the effects of calcium channel blocking drugs: comparison of verapamil and nifedipine.心率依赖性房室结传导及钙通道阻滞剂的作用：维拉帕米与硝苯地平的比较
J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):267-72. doi: 10.1097/00005344-198403000-00010.
10
引用本文的文献
1
The effects of verapamil on cerebrospinal fluid pressure in surgical patients.
J Anesth. 1987 Sep 1;1(2):132-6. doi: 10.1007/s0054070010132.
2
Haemodynamic effects of nifedipine and propranolol in patients with hypertrophic obstructive cardiomyopathy.硝苯地平与普萘洛尔对肥厚性梗阻性心肌病患者的血流动力学影响。
Br Heart J. 1982 Jul;48(1):19-26. doi: 10.1136/hrt.48.1.19.
3
Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipine.慢性稳定型心绞痛中的钙拮抗剂药物。维拉帕米与硝苯地平的比较。
Br Heart J. 1981 Nov;46(5):508-12. doi: 10.1136/hrt.46.5.508.
4
Role of calcium antagonists in cardiovascular therapy.钙拮抗剂在心血管治疗中的作用。
Br Heart J. 1981 Jul;46(1):8-16. doi: 10.1136/hrt.46.1.8.
5
Blood pressure and heart rate in patients with ischaemic heart disease receiving nifedipine and propranolol.接受硝苯地平和普萘洛尔治疗的缺血性心脏病患者的血压和心率
Br Med J (Clin Res Ed). 1982 Apr 17;284(6323):1148-51. doi: 10.1136/bmj.284.6323.1148.
6
Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.抗心绞痛治疗的客观评估：普萘洛尔、硝苯地平及其联合用药的双盲比较。
Br Med J. 1980 Jul 19;281(6234):184-7. doi: 10.1136/bmj.281.6234.184.
7
[Pharmacokinetics and cardiac effect of beta-acetyldigoxin and digitoxin in combination therapy with nifedipine].[β-乙酰地高辛和洋地黄毒苷与硝苯地平联合治疗的药代动力学及心脏效应]
Klin Wochenschr. 1984 May 15;62(10):451-7. doi: 10.1007/BF01726906.
8
Denmark: the elderly living in style.丹麦：老年人优雅生活。
Br Med J (Clin Res Ed). 1983 Oct 8;287(6398):1053-5. doi: 10.1136/bmj.287.6398.1053.
9
Acute and chronic haemodynamic and electrophysiological effects of nifedipine in patients receiving atenolol.硝苯地平对正在服用阿替洛尔的患者的急性和慢性血流动力学及电生理效应。
Br Heart J. 1983 Oct;50(4):383-9. doi: 10.1136/hrt.50.4.383.
10
Calcium antagonists. Clinical use in the treatment of arrhythmias.钙拮抗剂。在心律失常治疗中的临床应用。
Drugs. 1983 Feb;25(2):125-53. doi: 10.2165/00003495-198325020-00003.
本文引用的文献
1
Immediate effects of intravenous verapamil in cardiac arrhythmias.静脉注射维拉帕米对心律失常的即时效应。
Br Med J. 1972 Mar 11;1(5801):660-2. doi: 10.1136/bmj.1.5801.660.
2
Effect of verapamil on the noraml action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers.维拉帕米对犬心脏浦肯野纤维正常动作电位及钙依赖性慢反应的影响。
Circ Res. 1974 Feb;34(2):204-13. doi: 10.1161/01.res.34.2.204.
3
Effects of agents which inhibit the slow channel on sinus node automaticity and atrioventricular conduction in the dog.抑制慢通道的药物对犬窦房结自律性和房室传导的影响。
Circ Res. 1974 Feb;34(2):184-92. doi: 10.1161/01.res.34.2.184.
4
Verapamil in the treatment of paroxysmal supraventricular tachycardia.维拉帕米治疗阵发性室上性心动过速
Postgrad Med J. 1974 Jul;50(585):447-53. doi: 10.1136/pgmj.50.585.447.
5
Effects of nifedipine, a potent calcium-antagonistic coronary vasodilator, on atrioventricular conduction and blood flow in the isolated atrioventricular node preparation of the dog.强效钙拮抗型冠状动脉扩张剂硝苯地平对犬离体房室结标本的房室传导及血流的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1975;290(1):107-12. doi: 10.1007/BF00499993.
6
Effects of verapamil on sinus node function in man.维拉帕米对人体窦房结功能的影响。
Eur J Cardiol. 1978 Oct;8(3):379-94.
7
The relationship between posture, blood pressure and electrophysiological properties in patients with paroxysmal supraventricular tachycardia.
Arch Mal Coeur Vaiss. 1978 Mar;71(3):293-9.
8
The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade.硝苯地平对β-肾上腺素能受体阻断后犬心脏窦房结和房室结的影响。
Acta Pharmacol Toxicol (Copenh). 1978 Apr;42(4):287-91. doi: 10.1111/j.1600-0773.1978.tb02203.x.
Zotero 插件