Shephard R J
Br Heart J. 1979 Aug;42(2):133-8. doi: 10.1136/hrt.42.2.133.
The Ontario Multi-Centre Exercise-Heart trial is making a prospective study of 751 male subjects following well-documented episodes of myocardial infarction. Comparison is here made between the 50 participants who sustained a recurrence of their myocardial infarction, and the 701 participants who did not. Reinfarction was a little more likely with a history of multiple previous infarctions, but was unrelated to such indicators of infarct severity as symptoms, electrocardiographic abnormalities, enzyme changes, cardiac arrest, arrhythmia, or minimum systolic blood pressure. Features noted on admission to the trial, which may have an adverse effect, include smoking history and related symptoms, residual disability, shortness of breath, and angina of effort. The main physiological warning sign was a low and decreasing cardiac output at a submaximal work load, with a compensatory widening of arteriovenous oxygen difference. With the possible exception of exercise non-compliance, none of the adverse findings is sufficiently consistent to be of value when advising individual patients.
安大略多中心运动-心脏试验正在对751名有充分记录的心肌梗死发作后的男性受试者进行前瞻性研究。在此对50名心肌梗死复发的参与者和701名未复发的参与者进行比较。既往有多次梗死病史者再次梗死的可能性略高，但与梗死严重程度的指标如症状、心电图异常、酶变化、心脏骤停、心律失常或最低收缩压无关。试验入组时发现的可能有不良影响的特征包括吸烟史及相关症状、残留残疾、呼吸急促和劳力性心绞痛。主要的生理警示信号是在次最大工作量时心输出量低且不断下降，同时动静脉氧差代偿性增宽。除了可能存在运动不依从性外，没有一项不良发现足够一致，在为个体患者提供建议时没有价值。
