肥大细胞的体外分化。将免疫小鼠淋巴结和胸导管淋巴中的细胞培养于成纤维细胞单层上。
The in vitro differentiation of mast cells. Cultures of cells from immunized mouse lymph nodes and thoracic duct lymph on fibroblast monolayers.
作者信息
Ginsburg H, Lagunoff D
出版信息
J Cell Biol. 1967 Dec;35(3):685-97. doi: 10.1083/jcb.35.3.685.
Abstract
When cells from lymph nodes or thoracic duct of mice hyperimmunized with protein antigens are cultivated on embryo monolayers in the presence of the antigen, numerous clones of mast cells appear. The histochemical and ultrastructural characteristics of the cells permit their identification as mast cells and distinguish them from the phagocytic histiocytes that usually arise in abundance in similar cultures from unimmunized mouse cells or from immunized mouse cells cultured in the absence of the antigen. Only a few colonies of mast cells appeared in the latter cultures. The basis for the induction of mast cell differentiation is not known.
摘要
当用蛋白质抗原对小鼠进行超免疫后，取其淋巴结或胸导管中的细胞，在有抗原存在的情况下于胚胎单层细胞上培养时，会出现大量肥大细胞克隆。这些细胞的组织化学和超微结构特征使其能够被鉴定为肥大细胞，并将它们与吞噬性组织细胞区分开来，吞噬性组织细胞通常在来自未免疫小鼠细胞或在无抗原情况下培养的免疫小鼠细胞的类似培养物中大量出现。在后者的培养物中仅出现少数肥大细胞集落。肥大细胞分化诱导的基础尚不清楚。
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