使血红蛋白β链交联的双阿司匹林：双（3,5-二溴水杨酸基）琥珀酸酯和双（3,5-二溴水杨酸基）富马酸酯。
Diaspirins that cross-link beta chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate.
作者信息
Walder J A, Zaugg R H, Walder R Y, Steele J M, Klotz I M
出版信息
Biochemistry. 1979 Oct 2;18(20):4265-70. doi: 10.1021/bi00587a001.
PMID:486423
Abstract
Two double-headed aspirins, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, have been found to be potent acylating agents of intracellular hemoglobin (A or S) in vitro. Furthermore, each of these reagents cross-links beta chains of hemoglobin, probably at the beta cleft. The modified hemoglobins show increased oxygen affinities and reduced gelation or sickling tendencies.
摘要
已发现两种双头阿司匹林，即琥珀酸双（3,5 - 二溴水杨酸）酯和富马酸双（3,5 - 二溴水杨酸）酯，在体外是细胞内血红蛋白（A或S）的有效酰化剂。此外，这些试剂中的每一种都能使血红蛋白的β链交联，可能是在β裂隙处。修饰后的血红蛋白显示出氧亲和力增加，凝胶化或镰状化倾向降低。
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