Huang H, Olsen K W
Department of Chemistry, Loyola University of Chicago, IL 60626.
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):719-24. doi: 10.3109/10731199409117903.
Bis(3,5-dibromosalicyl) succinate and glutarate were used to crosslink met-, oxy- and deoxyhemoglobins. The added flexibility of these reagents compared to the fumarate analog resulted in a more heterogeneous product but did not greatly affect the maximum thermal stability of the crosslinked hemoglobins.
琥珀酸二（3,5 - 二溴水杨酸）酯和戊二酸二（3,5 - 二溴水杨酸）酯被用于交联高铁血红蛋白、氧合血红蛋白和脱氧血红蛋白。与富马酸类似物相比，这些试剂增加的柔韧性导致产物更加不均一，但对交联血红蛋白的最大热稳定性影响不大。
